NKEK13009U Protein Structure and Function
MSc Programme in Nanoscience
Protein science is central in the fundamental understanding of how organisms function, and in the application of proteins in medicine and biotechnology. The function of proteins is carried out through their three-dimensional structure and dynamics. The aim of this course is to guide students from Chemistry, Biochemistry, Nanotechnology, Biotechnology and related disciplines, who already have a basic knowledge of protein chemistry, through more advanced aspects of protein science based on critical reading of original literature.
The course will cover several aspects of the relationship between protein structure and function by going into depths into several case studies primarily through reading of original literature. A short introduction to biochemical and biophysical techniques to study proteins is also given. Aspects of structure and function of enzymes (particularly proteases and carbohydrate-active enzymes), transcription factors, membrane proteins, intrinsically unfolded proteins and designed proteins will be covered, with other topics varying from year to year. Two themes will also run throughout the course: the role of proteins in disease and proteins as biotechnological tools for sustainable industrial applications. A short practical introduction to protein sequence and structure databases and molecular graphics programs will be given as part of the course.
- The student must be able to gather and critically evaluate relevant information on specific aspects of protein structure and function from the scientific literature and databases
-The student must be able to relevantly integrate the gathered information in discussion of protein chemistry, structure and function in the broader context of several disciplines, for example medicine and biotechnology
The students must be able to:
- independently read and evaluate original research articles in english and critically describe how the experiments give information on the relationship between protein structure and function.
- formulate themselves precisely both orally and in writing in english when discussing protein structure and function.
- search for relevant information in protein sequence and structure databases
- illustrate important points related to a protein's structure and function by preparing figures using a molecular graphics program
- recognize and describe different types of structures and functional mechanisms for proteins.
The student must demonstrate to have acquired knowledge on the structure and functions of the specific proteins covered in the course, as well as the general mechanisms by which protein structure dictates its function, e.g. catalysis and molecular recognition
Most of the curriculum consists of original literature (reviews and articles). Details will be found on Absalon. A textbook is also used: in 2018 this was David Whitford (2005) ”Proteins structure and function” Wiley, but maybe subject to change. Please check on Absalon or with the responsible teacher before you buy the textbook.
Academic qualifications equivalent to a BSc degree is recommended.
- Class Instruction
- Practical exercises
- 7,5 ECTS
- Type of assessment
- Written assignment, 10 daysOral examination, 20 minutesEvaluation consists of a written home assignment based on original articles. The oral examination is based primarily on the written assignment and the original articles it is based on, but also on related topics covered in the course. The mark is based on an overall evaluation of both written and oral performance.
- Exam registration requirements
Attendance of at least 60% of lessons. Oral presentation of 1-3 articles (the number will be set in the first week of course, once the number of participants is known).
- Only certain aids allowed
The student must take a copy of his written assignment and the articles it is based on to the exam.
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Several internal examiners
As the ordinary exam. If no written assignment was handed in for the ordinary exam, a new assignment will be set. If an assignment was handed in at the ordinary exam, no new written assignment is necessary.
If the student attended less than 60 % of the course, an electronic quiz covering the whole curriculum must be passed. If the student did not hold one or more of the compulsory presentations, powerpoint slides for the missed presentatons must be handed in.
These requirement must be satisfied at latest three weeks before the re-examination. The student is required to contact the responsible teacher at least 4 weeks before the re-examination to make the necessary practical arrangements.
Criteria for exam assesment
See Learning outcome