NKEK13007U Reactions and Synthesis in Medicinal Chemistry (KemiMed)
MSc Programme in Chemistry
MSc Programme in Chemistry with a minor subject
MSc Programme in Medicinal Chemistry
The topics are: C-alkylation; Formation and reactions of enolates; Stereospecific aldol-additions; Chiral auxilaries; Functional groups and molecular carbon framework; Movement of electrons in chemical reactions; Functional group transformations, including reductions and oxidations; Mitsunobu and related reactions; Alfa nucleophiles; Understanding migration, rearrangement and fragmentation reactions; Radical reactions; Reactions involving carbenes and nitrenes; Reactions of boranes and stananes; Electrophiles from electronegative atoms; The influence of the electronegativity of atoms on chemical bonds and their stability; Pericyclic reactions; Click-chemistry;Transition-metal catalyzed reactions including a variety of cross-coupling reactions; Electrophilic and nucleophilic aromatic substitution reactions; Charge dissipation and resonance; Framework reductions and oxidation reactions; Understanding of chemistry in 3D, assisted by MM2 of the Chem3D software available at KU for students; Expecting the unexpected; Case stories from the medicinal industry: Using advanced organic chemistry in synthesis of natural and medicinal products.
Competencies
Be able to analyze a complex synthetic problem and plan a feasible
synthesis.
Be able to describe the precise movement of electrons in chemical
reactions and understand the influence of the third dimension in
chemical transformations. Be able to analyze scientific papers
dealing with synthetic problems and spot inconsistencies. Be
able to present the different topics of the course in an organized
and scientific manner.
Skills
Apply the aquired organic chemistry knowledge to the
synthesis of a given target molecule. Mastering digital
visualization of chemical transformations. Be able to transpose
known chemistry to new synthesis problems using knowledge of
probable electron migrations in bond formation, rearrangements and
fragmentations
Knowledge
Following the course an in depth knowledge of modern organic
synthesis in 3-dimensions according to the above content of the
course will be achieved.
Will be announced on Absalon.
Academic qualifications equivalent to a BSc degree is recommended.
- Category
- Hours
- Lectures
- 28
- Preparation
- 290
- Theory exercises
- 70
- Exam
- 24
- Total
- 412
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- Credit
- 15 ECTS
- Type of assessment
- Oral examination, 30 minutes
- Type of assessment details
- Ingen forberedelsestid. The student presents 1 of 20 topics, which are made available to the students in the fifth week of the block. After the presentation the student is asked specific and general questions in the topic and related material.
- Aid
- Only certain aids allowed
A short powerpoint, pdf or similar file with a summary for each of the examination topics for presentation of the topic selected by the student.
A personal laptop with HMDI connection may be used for the presentation
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Several internal examiners
- Re-exam
The reexamination is a 30 minutes oral exam based on a set of questions related to the textbook, where the student picks one at random.
The questions will be made public on the course homepage three weeks before the reexam.
Criteria for exam assesment
See Learning Outcome
Course information
- Language
- English
- Course code
- NKEK13007U
- Credit
- 15 ECTS
- Level
- Full Degree Master
- Duration
- 2 blocks
- Placement
- Block 1 And Block 2
- Schedule
- A
- Course capacity
- No limitation – unless you register in the late-registration period (BSc and MSc) or as a credit or single subject student.
Study board
- Study Board of Physics, Chemistry and Nanoscience
Contracting department
- Department of Chemistry
Contracting faculty
- Faculty of Science
Course Coordinators
- Morten Peter Meldal (meldal@chem.ku.dk)