NFOK24002U Downstream Processing
MSc Programme in Biosolutions
The course will familiarize the students with the principles and challenges of downstream processing in bio-based production systems. The course will cover principles of unit operation and the integration of the different process steps, incorporating the effect of the material on the selection of relevant downstream processing technologies. Cleaning-in-Place for bio-processes will be discussed, being an integral part of production operation and planning. The theory will cover both existing technologies and state-of-the-art / future developments. Efficiency, robustness and process performance will be central as well as instrumentation and methodologies from the area of Process Analytical Technology / Industry 4.0 for process monitoring and control.
The course will train students to in the use of the following technologies in biotechnology / novel biosolutions.
Knowledge:
- Harvesting from soluble or intercellular expression
- Product and material understanding plus processing; basic principles such as purification, size and affinity
- Separation technologies based on size, i.e. centrifugation, membranes, industrial chromatography
- Freeze drying and spray Drying, including energy efficiency and optimization
- Stability through the supply chain, including side streams and formulation
- Cleaning-in-Place in the biotech industry
- Process monitoring and control, including instrumentation and data-driven decision making in the bio-process industry
Skills:
- Formulate challenges and solutions in downstream processing in the biotech industry
- Evaluate alternative production pathways in downstream processing, including (energy) efficiency, robustness and sustainability criteria
Competences:
- Analyze and evaluate downstream processes
- Suggest improvements / alternatives on downstream processing to enhance quality / sustainability
- Design and improve a strategies for a new products / streams
- Interaction with the (upstream and downstream) costumers
See Absalon for a list of course literatures. Source code and toolboxes for the statistical software is available via Absalon.
- Category
- Hours
- Lectures
- 50
- Preparation
- 77
- Theory exercises
- 30
- Exercises
- 48
- Exam
- 1
- Total
- 206
- Credit
- 7,5 ECTS
- Type of assessment
- Oral examination, 20 minutes (no preparation)
- Type of assessment details
- At the individual, oral exam the students are quizzed on the curriculum / theory of the course.
- Exam registration requirements
The students have to have presented mini-assignments / exercises during the course (not graded). Each participant will make one presentation during the course, and this contribution by the student is a requirement to take part in the exam.
- Aid
- Written aids allowed
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Several internal examiners
- Re-exam
Same as the ordinary exam.
Mini-assignments / exercises (not graded) must be handed in 2 weeks before the re-exam.
Criteria for exam assesment
See Learning Outcome
Course information
- Language
- English
- Course code
- NFOK24002U
- Credit
- 7,5 ECTS
- Level
- Full Degree Master
- Duration
- 1 block
- Placement
- Block 3
- Schedule
- CThe course is taught in Kalundborg
- Course capacity
- 40
The number of places might be reduced if you register in the late-registration period (BSc and MSc) or as a credit or single subject student.
Study board
- Study Board for the Biological Area
Contracting department
- Department of Food Science
Contracting faculty
- Faculty of Science
Course Coordinators
- Franciscus Winfried J van der Berg (2-75714f757e7e733d7a843d737a)