SMPS20006U Pharmaceutical Analytical Chemistry

Volume 2023/2024
Education

MSc Programme in Pharmaceutical Sciences (English programme): Study track II ('Drug Development' track) - compulsory

MSc Programme in Pharmaceutical Sciences (English programme): Study track I & III - elective

MSc Programme in Medicinal Chemistry - elective

Content

Study groups and exercises constitute an integrated course package. The course provides a background for selecting and developing analytical methods and assessing the reliability of analytical data. A variety of analytical techniques are described with regard to their use in quantitative determination and identification. Teaching will focus on the design and use of apparatus as well as potential sources of error. There will also be focus on quality assurance and validation of analytical methods, including the significance of linearity, accuracy, precision, sensitivity, determination limits, blind values, selectivity and interference.

The students take turns giving presentations on the performed practical exercises and the finding of the exercises are discussed and related to the theory of the applied instrumentation. In the practical exercises, students work with fixed demonstrations of separation and detection methods. They simultaneously work on a project where they plan and try out a number of these techniques on a given drug. The analytical techniques are UV/VIS spectrophotometry, liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and atomic absorption spectrometry (AAS). The students carry out experiments in groups and submit a joint report. Reports are assessed by the teacher and discussed on return.

Learning Outcome

To enable students to develop and use analytical chemical methods in connection with development of drug substances, as well as identification and quality assessment of drugs and excipients.

At the end of the course, students should be able to:

Knowledge

  • explain the principle of the techniques, their areas of application and potential sources of error
  • understand the methodological terminology required for reading literature and writing reports
  • assess the reliability of analytical data
  • report experiments briefly, clearly and unambiguously.

 

Skills

  • perform quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied
  • perform validation of an analytical method.

 

Competences

  • Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods
  • D.C. Harris: Quantitative Chemical Analysis, 10th edition, W.H. Freeman and Company, New York, 2020.
  • Compendium in Pharmaceutical Analytical Chemistry, latest edition, Department of Pharmacy, University of Copenhagen. Is available on the course home page via Absalon.
Applicants must have completed the course “Organic Chemistry I - Physicochemical Properties” or a similar course in organic chemistry. In application for enrolment on Pharmaceutical Analytical Chemistry, applicants must provide documentation for equivalent competencies, in the form of a course description and the grade from passing the course.
•Exercises/project: 16 four-hour sessions plus report writing
•Discussion classes: 8 two-hour sessions
  • Category
  • Hours
  • Preparation
  • 34
  • Theory exercises
  • 16
  • Practical exercises
  • 64
  • Project work
  • 92
  • Total
  • 206
Written
Oral
Collective
Credit
2,5 ECTS
Type of assessment
Continuous assessment
Type of assessment details
In order to obtain the course certificate the student should participate actively during laboratory exercises and submit and gain approval of all laboratory reports.
Marking scale
passed/not passed
Censorship form
No external censorship
Criteria for exam assesment

To achieve a course certificate the student must be able to:

Knowledge

  • explain the principle of the techniques, their areas of application and potential sources of error
  • understand the methodological terminology required for reading literature and writing reports
  • assess the reliability of analytical data
  • report experiments briefly, clearly and unambiguously.

 

Skills

  • perform quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied
  • describe the analytical methods applied in selected reports and demonstrate ability to perform quantitative determinations based on analytical data.

 

Competences

  • Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods
Credit
5 ECTS
Type of assessment
Written examination, 2 hours under invigilation
Type of assessment details
Multiple-choice exam.
Aid
Written aids allowed

Find more information about written on-site exams in the exam rooms, incl. information about standard programs on the exam PCs at KUnet

Written on-site exam - KUnet

In addition to the standard programs digital notes are permitted for this exam. It is allowed to upload notes for the ITX exam via digital exam. You will find a link to this feature from your exam in Digital Exam.

Marking scale
7-point grading scale
Censorship form
No external censorship
Re-exam

10 or fewer students registered for reexam:

Type of assessment: Oral examination

Assessment details: 20 minutes examination

Preparation: 5 minutes

Aids: Certain aids. Calculator, books and notes (No computer).

Criteria for exam assesment

To achieve the grade 12 the student must be able to:

Knowledge

  • explain the principle of the techniques, their areas of application and potential sources of error
  • understand the methodological terminology required for reading literature and writing reports
  • assess the reliability of analytical data
  • report experiments briefly, clearly and unambiguously.

 

Skills

  • perform quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied
  • describe the analytical methods applied in selected reports and demonstrate ability to perform quantitative determinations based on analytical data.

 

Competences

  • Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods