NKEK13007U Reactions and Synthesis in Medicinal Chemistry (KemiMed)

Volume 2021/2022
Education

MSc Programme in Chemistry
MSc Programme in Chemistry with a minor subject
MSc Programme in Medicinal Chemistry

Content

The topics are: Formation and reactions of enolates; Stereospecific aldol-additions; Chiral auxilaries; Reduction of organic funtional groups; Pericyclic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution and methods for determination of optical purity; Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic Aromatic substitution  reactions; Oxidation reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems.and reagents; Patents and how to use the patent literature.

Learning Outcome

 

Competencies
Be able to analyze a complex synthetic problem and plan a feasible synthesis.
Be able to analyze scientific papers and patents dealing with synthetic problems and be able to spot inconsistent claims.


Skills
Apply the aquired knowledge on organic synthesis on a given target molecule. Be able to translate known methodologies to new problems.

Knowledge
Have an in depth knowledge of modern synthetic organic synthesis according to the content of the course.

 

Will be announced on Absalon

Basic competencies physical chemistry, quantum chemistry, inorganic chemistry are necessary and intermediate competencies in organic chemistry and organic synthesis  are necessary (equivalent to KemiOrg and (Vid)OrgSyn).

Academic qualifications equivalent to a BSc degree is recommended.
Lectures, problem solving in class and written exam
  • Category
  • Hours
  • Lectures
  • 26
  • Preparation
  • 333
  • Theory exercises
  • 52
  • Exam
  • 1
  • Total
  • 412
Feedback by final exam (In addition to the grade)
Credit
15 ECTS
Type of assessment
Written examination, 4 timer under invigilation
...
Aid
Without aids
Marking scale
7-point grading scale
Censorship form
No external censorship
flere interne bedømmere
Re-exam

The reeksamination is a 30 minutes oral exam based on a set of questions related to the textbook, where the student picks one at random.

The questions will be made public on the course homepage three weeks before the reexam.

 

Criteria for exam assesment

See Learning Outcome