SMOK17001U Camcelled spring 2019! Development and Clinical Implementation of Innovative Treatment Modalities: From Initial Idea to Clinical Application
Msc in Molecular Biomedicine - restricted elective
The course will explore the basic molecular and cellular concepts and principles related to the development of novel and innovative treatment modalities covering medical applications to treatment and prevention of human diseases. To ensure that students acquire skills pertinent to the process of translation of basic discoveries into clinical practice, the continuum from basic research to clinical implementation is addressed, with emphasis on the concept of personalized medicine and the use of biomarkers. Throughout the course cancer cases will be used to illustrate key concepts. Disease models and molecular therapies will also be discussed and related to the biological makeup of diseased cells.
The following topics will be addressed during the course:
Signal transduction
Genome aberrations as biomarkers
Identification and selection of drug candidates including establishment of functional cellular assays
Preclinical and clinical development of drugs and companion diagnostic biomarkers
Preclinical in vivo assays in cancer
Regulatory and patent policies
Clinical trials of novel drugs including Good Clinical Practice
Innovative trial design
How to start your own biotech company
Knowledge:
A student who has met the objectives of the course will be able to:
Understand and explain the fundamental aspects and principles of translational medicine
Understand preclinical drug development
Understand the principles of drug screening and testing and the overall requirements for preclinical models
Understand requirements for entering into clinical trials and modern clinical trial designs
Understand the different steps from academic research to commercialization
Skills:
Upon completion of the course students should be able to:
Demonstrate a critical understanding of the causation and treatment of of major diseases like cancer
Apply knowledge to offer opinions and understanding of novel treatment strategies, with focus on personalized/precision medicine
Critically evaluate experimental animal models used in the development of investigational drugs
Understand and explain the major steps involved in the path from laboratory discovery to patient treatment with a new drug
Competences:
Upon completion, students will be better prepared to start a career in a biotechnology or pharmaceutical setting. They'll have had experience working on how one identifies a target and bring it all the way through to preclinical evaluation and clinical testing.
The Biology of Cancer, Second Edition by Robert A. Weinberg. Also additional lselected articles from the primary literature will be provided
- Category
- Hours
- Exam
- 4
- Lectures
- 40
- Preparation
- 112
- Theory exercises
- 60
- Total
- 216
Open for credit transfer students. Apply here:
http://healthsciences.ku.dk/education/other-programme-options/credit-transfer-students/
- Credit
- 7,5 ECTS
- Type of assessment
- Written examination, 4 hours under invigilationContinuous assessmentWritten exam with essay type questions as well as short questions and multiple option questios. Exam weighs 80% of final grade, remaining 20% from class evaluations.
- Aid
- Without aids
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
No external censorship
Several internal examiners/co-examiners
Criteria for exam assesment
Demonstration of a critical understanding of the causation and treatment of of major diseases like cancer
Ability to formulate opinions and show understanding of novel treatment strategies, with focus on personalized/precision medicine
Critically evaluate experimental animal models used in the development of investigational drugs
Understand and explain the major steps involved in the path from laboratory discovery to patient treatment with a new drug
Course information
- Language
- English
- Course code
- SMOK17001U
- Credit
- 7,5 ECTS
- Level
- Full Degree Master
- Duration
- 1 block
- Placement
- Block 3
- Schedule
- B
- Course capacity
- planned for a maximum of 60 students
- Study board
- Study Board for the Biological Area
Contracting department
- Department of Drug Design and Pharmacology
Contracting faculty
- Faculty of Health and Medical Sciences
Course Coordinators
- José Moreira (jomo@sund.ku.dk)
Lecturers
José M.A. Moreira, Nils Brünner, Jan Stenvang, Stine Friis, PhD students from the Section of Molecular Disease Biology, and invited guest lecturers.