NKEK13007U Reactions and Synthesis in Medicinal Chemistry (KemiMed)

Volume 2018/2019
Education

MSc Programme in Chemistry
MSc Programme in Medicinal Chemistry

MSc Programme in Chemistry with a minor subject

Content

The topics are: Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems.

Learning Outcome

 

Competencies
Be able to analyze a complex synthetic problem and plan a feasible synthesis.
Be able to analyze scientific papers and patents dealing with synthetic problems and be able to spot inconsistent claims.


Skills
Apply the aquired knowledge on organic synthesis on a given target molecule. Be able to translate known methodologies to new problems.

Knowledge
Have an in depth knowledge of modern synthetic organic synthesis according to the content of the course.

 

Literature

Will be announced on Absalon

Basic competencies physical chemistry, quantum chemistry, inorganic chemistry are necessary and intermediate competencies in organic chemistry and organic synthesis  are necessary (equivalent to KemiO and (Vid)OrgSyn).
Lectures, problem solving in class and written take-home assignments
  • Category
  • Hours
  • Exam
  • 1
  • Lectures
  • 26
  • Preparation
  • 333
  • Theory exercises
  • 52
  • Total
  • 412
Credit
15 ECTS
Type of assessment
Oral examination, 30 min
The exam is an oral examination based on one of the take-home assignments chosen randomly (by lot). There is no preparation time
Exam registration requirements

There will be 11 take-home assignments during the course, which will have to be approved in order to take the exam.

Aid
Without aids
Marking scale
7-point grading scale
Censorship form
No external censorship
flere interne bedømmere
Re-exam

The re-examination is also an oral examination based on one of the take-home assignments chosen randomly (by lot).

All missing take home assignments must be submitted no later than two weeks prior to reexam.

Criteria for exam assesment

See Learning Outcome