NFYK16004U Medical Physics 2
MSc Programme in Physics
Medical imaging:
Medical imaging informatics
CT imaging: Back projection algorithms, scatter correction algorithms etc.
Magnetic resonance imaging (MRI). Basic physical principle behind magnetic resonance, image formation and the possibility to distinguish between different tissues – combination with other diagnostic tools.
Physical principles behind Positron Emission Tomography (PET). Applications with metabolic markers like FDG. Production of nuclear tracers
Physical principles behind radiation dose planning. Boltzmann’s energy transport in tissue.
Advanced dose calculation exercise
Cancer biology and side effects.
Estimation of risk of toxicity based on a given radiation dose distribution in a normal tissue in the vicinity of a tumor. Methodology for generating outcome prediction models from clinical data. Connection with linear-quadratic model of biological effect. Therapeutic issues related to hypxia or other types of tumor resistance.
Project:
The student will choose a theoretical or experimental project which will be based on one or several topics which are covered in week 1 through 6 of the course. The chosen project will have a duration that covers the last 1.5 weeks of the course and the written report should be at most 5 A4 pages with possible appendices including data/code or supplementary figures. A maximum of 2 students per project is allowed (and encouraged).
Skills
- Explain the basic physical principles behind the diagnostic tools, CT, MRI and PET.
- Explain how the different medical imaging modalities can visualize different aspects of tissue.
- Describe the physics behind dose planning and energy transport in tissue and apply this knowledge to perform theoretical dose calculations with the appropriate software.
- Explain the biology of tumor growth the relevance of angiogenesis, hypoxia and metastatic potential
- Describe basic statistical methods used to assess the effect of radiation with respect to tumor control and toxicity.
- Demonstrate the use of models for quantifying radiation induced damage to irradiated tissue.
Knowledge
The student knows how different medical images of the human anatomy
and physiology such as CT, MRI and PET are produced and used to
visualize e.g. tumors. Also, the student knows how the principles
behind modern treatment planning systems of radiation dose and how
to carry out simple dose plans and understand the principles of
assessing the biological effect of a radiation dose plan. The
course will give the student advanced insight into important
subjects related to the work carried out by a medical physicist who
is working with radiation oncology or diagnostics.
Competences
The course will provide the student with a basic knowledge for
designing and performing simple imaging experiments and evaluate
and explain the outcome of the experiments. The course will provide
the student with a basic knowledge regarding the physical mechanism
behind advanced imaging techniques which are used extensively at
Danish hospitals and research centers. Finally, the student will
have general insight into the biology of cancer tumors and the side
effects that occur in irradiated healthy tissue and the data
analytics methods used to quantify the effect of radiation on
tissue.
Will be announced on Absalon
- Category
- Hours
- Lectures
- 28
- Preparation
- 64
- Project work
- 80
- Theory exercises
- 34
- Total
- 206
- Credit
- 7,5 ECTS
- Type of assessment
- Written assignment, 1.5 weeksOral examination, 25 minutesWritten report based on the theoretical or experimental exercise chosen by the student, cf. content/project.
The final grading will be focused on the 25 minutes oral examination (without preparation time) with weight on the written report. The oral reporting of the selected assignment will be expected to fill a substantial part of the oral presentation by the student, but knowledge of the course content will also be assessed at the oral exam and be important for the final grade. - Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
several internal examiners
- Re-exam
Same as original exam. The same written assignment may be re-used by the student if desired. Given the relatively high weight on the exercise for the final grade, however, the students are encouraged to update their work if a more substantial improvement of grade is desired. The written report must be (re-)submitted no later than 2 weeks before the re-exam.
Criteria for exam assesment
See Learning Outcome
Course information
- Language
- English
- Course code
- NFYK16004U
- Credit
- 7,5 ECTS
- Level
- Full Degree Master
- Duration
- 1 block
- Placement
- Block 3
- Schedule
- B
- Course capacity
- no restriction
- Continuing and further education
- Study board
- Study Board of Physics, Chemistry and Nanoscience
Contracting department
- The Niels Bohr Institute
Course Coordinators
- Jens Morgenthaler Edmund (11-5570797e39706f7880796f4b796d74397680396f76)
Lecturers
The course primarily uses external teachers from Herlev og
Gentofte Hospital and Rigshospitalet:
Jens M. Edmund jens.edmund@regionh.dk
Ivan Vogelius ivan.richter.vogelius@regionh.dk