SFKKB9001U Pharmacokinetics and Pharmacodynamics
MSc in Pharmaceutical Sciences - elective, MSc in Medicinal Chemistry - elective, Cand.Scient.Pharm. - elective, Cand.Pharm. - elective
Lectures covering PK-PD relationships, as well as distribution, metabolite kinetics, effect at receptor and ionchannel level, effect measurement, dose-effect relationships, population methods, simulation of PK-PD relationships and variability in PK-PD response and dosing to different patient populations.
Computer sessions for pharmacokinetic pharmacodynamic modeling using the program Phoenix WinNonlin and Microsoft Excel.
At the end of the course, students are expected to be able to:
Knowledge
- Demonstrate knowledge of pharmacokinetic (PK) and pharmacodynamic (PD) in the individual as well as the population
- Understand how to calculate PK and PD parameters and use them in a quantitative description of the interaction between a drug and the body over time.
- Obtain knowledge on variability in patient populations
Skills
- Obtain insight and hands-on experience with pharmacokinetic and –dynamic data analysis, based on different examples of plasma concentration-time course linked to therapeutic response.
- obtain experience with the modelling software Phoenix WinNonlin and Microsoft Excel for data analysis.
- Apply knowledge on variability in patient populations to a PKPD analysis that can be used to describe variability in response in different patient segments and in drug research and illustrate development within the pharmaceutical industry.
Competences
- Design dosing strategies in different clinical situations based on their knowledge about PKPD (e.g. taking variations such as demographics, organfunction, pharmacogenetics, comobidity and interactions into account).
- Design experiments for the drug research and development based on their knowledge about PKPD
- M. Rowland and T. Tozer, Clinical Pharmacokinetics and Pharmacodynamics, ed. 4, 2011
- Notes and lecture hand-outs available on the course homepage
Tutorials/computer sessions: 15 hours
- Category
- Hours
- Exam
- 85
- Lectures
- 24
- Preparation
- 78
- Theory exercises
- 15
- Total
- 202
Open for Danish and international guest students. For application details look here: http://sund.ku.dk/uddannelse/andre-uddannelsestilbud/meritstuderende/.
- Credit
- 7,5 ECTS
- Type of assessment
- Written examination, 3 hours under invigilationPermitted aids: Textbooks, all written course material from the homepage.
Examiners: Course teachers - Aid
All written aids allowed.
Refer to the IT exams homepage link where the standard programs and IT tools available for the students’ disposal during IT exams under The Faculty of Health and Medical Sciences are listed.
During the exam, students will have access to MathType and the possibility to use a USB stick (for notes etc.)
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Criteria for exam assesment
To achieve the grade 12 the student must be able to:
Knowledge
- Demonstrate knowledge of pharmacokinetic (PK) and pharmacodynamic (PD) in the individual as well as the population
- Understand how to calculate PK and PD parameters and use them in a quantitative description of the interaction between a drug and the body over time.
- Obtain knowledge on variability in patient populations
Skills
- Obtain insight and hands-on experience with pharmacokinetic and –dynamic data analysis, based on different examples of plasma concentration-time course linked to therapeutic response.
- obtain experience with the modelling software Phoenix WinNonlin and Microsoft Excel for data analysis.
- Apply knowledge on variability in patient populations to a PKPD analysis that can be used to describe variability in response in different patient segments and in drug research and illustrate development within the pharmaceutical industry.
Competences
- Design dosing strategies in different clinical situations based on their knowledge about PKPD (e.g. taking variations such as demographics, organfunction, pharmacogenetics, comobidity and interactions into account).
- Design experiments for the drug research and development based on their knowledge about PKPD
Course information
- Language
- English
- Course code
- SFKKB9001U
- Credit
- 7,5 ECTS
- Level
- Full Degree MasterFull Degree Master choice,Part Time Master
- Duration
- 1 block
- Placement
- Block 2
- Schedule
- A
- Course capacity
- 30 students
- Study board
- Study Board of Pharmaceutical Sciences
Contracting department
- Department of Drug Design and Pharmacology
Course responsibles
- Trine Meldgaard Lund (10-77756c7168316f7871674376787167316e7831676e)