NFYK16004U Medical Physics 2
M.Sc. Physics
Cancer biology and side effects
- Cancer cell biology, advanced radiobiology, therapeutic issues related to hypoxia in tumors, the development of tumors during radiation fractions. Interaction between tumors with surrounding tissue and different hallmarks of cancer growth.
- Statistics of different treatment modalities with respect to recurrence of cancer
- Damage to surrounding organs. Anatomy and physiology of surrounding organs - models for describing damage.
Diagnostic imaging
- Magnetic resonance imaging (MRI). Basic physical principle behind magnetic resonance
- Magnetic Resonance diagnostics, a key modality in medicine- the possibility to distinguish between different tissues – combination with other diagnostic tools.
- CT imaging: Back projection algorithms, scatter correction algorithms etc. Dose measurement from CBCT
- Physical principles behind Positron Emission Tomography (PET). Applications with metabolic markers like FDG.
- Production of nuclear tracers
Radiation planning
- Physical principles behind radiation dose planning. Boltzmann’s energy transport in tissue.
- Advanced dose calculation theoretical exercise
Exercises:
The student will choose a theoretical or experimental project
which will be based on one or several topics which are included in
the course.
The chosen exercise will cover at least a 1.5 weeks of the course
and the written report should be at most 5 A4 pages with possible
appendices with data/code or supplementary figures.
Skills
After completing the course, the student receiving the top grade
should be able to:
- Explain the biology of tumor growth and the development of angiogenesis, hypoxia and how metastatic cell growth differs from non-metastatic cell growth
- Describe the statistics behind cancer survival in relation to different treatment modalities
- Apply models for quantifying radiation inflicted damage to surroundings organs
- Explain the basic physical principles behind the diagnostic tools, PET and MRI
- Perform theoretical dose calculations
- Describe the physics behind dose planning and energy transport in tissue and apply this knowledge to perform theoretical dose calculations
- Describe how nuclear tracers are produced
Knowledge
The student knows how magnetic resonance can be used in imaging of
the human anatomy and physiology and in particular how MRI can be
used as a diagnostic tool to detect e.g. tumors. Also, the student
knows how cancer can be detected using PET to detect tumors with
high metabolic activity. The course will give the student advanced
insight into important subjects related to the work carried out by
a medical physicist who is working with radiation oncology or
diagnostics.
Competences
The course will provide the student with a basic knowledge for
designing and performing simple imaging experiments and evaluate
and explain the outcome of the experiments. The course will provide
the student with a basic knowledge regarding the physical mechanism
behind advanced imaging techniques which are used extensively at
Danish hospitals and research centers. Finally, the student will
have general insight into the biology of cancer tumors and the side
effects that occur in irradiated healthy tissue.
Will be announced later
- Category
- Hours
- Lectures
- 28
- Preparation
- 64
- Project work
- 80
- Theory exercises
- 34
- Total
- 206
- Credit
- 7,5 ECTS
- Type of assessment
- Written assignmentOral examination, 25 minutesWritten report based on the theoretical or experimental exercise chosen by the student, cf. content/exercises.
The final grading will be focused on the 25 minutes oral examination with limited (~20%) weight on the written report. However, the oral reporting of the selected assignment will be expected to fill a substantial part of the oral presentation by the student and will be be important for the final grade. - Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
several internal examiners
- Re-exam
Same as original exam. The same written assignment may be re-used by the student if desired. Given the relatively heigh weight on the exercise for the final grade, however, the students are encouraged to update their work if a more substantial improvement of grade is required. The written report must be (re-)submitted no later than 2 weeks before the re-exam.
Criteria for exam assesment
See Learning Outcome
Course information
- Language
- English
- Course code
- NFYK16004U
- Credit
- 7,5 ECTS
- Level
- Full Degree Master
- Duration
- 1 block
- Placement
- Block 3
- Schedule
- B
- Continuing and further education
- Study board
- Study Board of Physics, Chemistry and Nanoscience
Contracting department
- The Niels Bohr Institute
Course responsibles
- Kim Splittorff (5-75726e6b764270646b306d7730666d)
Lecturers
Ivan Vogelius ivan.richter.vogelius@regionh.dk