SVEK14001U Laboratory Animal Science category C
MSc Programme in Biology-Biotechnology
Veterinærstuderende på alternativ differentiering
Studerende på natur- og sundhedsvidenskabelige studieretninger
The course includes the following topics:
Legislation, ethics and welfare, comparative and basic biology, nutrition, health, genetics, housing and facilities, occupational health, pain relief incl. anaesthesia and analgesia, experimental design and animal models.
The course is a function A/B/D course according to the EU
Directive 2010/63 /EU Article 23.2 (previously designated
category C) accredited by the Federation of European
Laboratory Animal Science Associations as well as the Ministry of
Food, Agriculture and Fisheries under the Danish Government.
The course gives as practical and theoretic introduction to handling, housing and using laboratory animals and how to replace, refine and reduce the use of live animals for research.
The course adheres to the more detailed learning outcomes described in the EU guidance paper 'A working document on the development of a common education and training framework to fulfill the requirements under the Directive' (http://ec.europa.eu/environment/chemicals/lab_animals/pdf/Endorsed_E-T.pdf).
Having completed the course it is expected that the student has the following:
The student knows
- that animal experimentation is complicated and requires current training to secure the well-being of the animals and the scientific outcome
- the biological basis of laboratory animal breeding and maintenance, housing and management including basic genetics and reproduction, health monitoring, housing and handling (pre-, intra and post-procedural).
- the legal basis for animal experimentation
- the scientific methods applied within animal experimentation including blood sampling, injections, principles for drug-development and testing, anesthesia and analgesia and evaluation of pain -and stress related behaviour in laboratory animals
- the basic biology of laboratory animals including behavioural and physiological needs.
- basic knowledge relating to design and evaluation of studies using live animals
The student is able to
- do self training on handling and procedures in the most common laboratory animals
- explain the basic principles on how to use animals for research
- apply principles of procedures on their future experiments
- reflect over the ethical basis for the use of animals for research
The student is able to
- perform basic handling of common rodents when used for research
- perform basic animal experiments
- achieve a personal license to design and perform animal experimentation within the European Union according to the EU Directive 2010/63 /EU Article 23.2 and the Danish executive order 88 of 30/01/2013 §56.
Hau, J. & Schapiro SJ: Handbook of Laboratory Animal Science, 3nd ed., Vol. 1, CRC Press, Roca Raton, 2011.
Additional review papers.
Animal experimentation legislation.
Exercise manual for Laboratory Animal Science (will be placed on Absalon).
Lectures and on-line material on Absalon
- 7,5 ECTS
- Type of assessment
- Written examination, 2 hours under invigilationWritten exam at Peter Bangs Vej with multiple choice, short questions and short essays.
- Exam registration requirements
80 % attendance to practical exercises. Demonstration of performance for an instructor during the exercises.
- Without aids
- Marking scale
- passed/not passed
- Censorship form
- No external censorship
- Exam period
More than one internal examiner Examination week, block 2, week structure C
Criteria for exam assesment
To pass the exam the student shall able to:
- Account for well-being in laboratory animals
- Reproduce the statutory rules and provisions on laboratory animals and studies
- Account for the comparative biology of frequently used laboratory animal species
- Describe ethics in animal studies
- Explain animal models and study design
- Account for gene-modified laboratory animals as models
- Describe the importance of environmental factors for homeostasis and study results
- Account for the handling and administration of drugs and for blood sampling
- Account for working environment in the animal stables - allergies and zoonoses
- Describe diseases and health control in laboratory animals
- Describe the genetics and standardization of laboratory animals
- Account for principles for breeding of laboratory animals
- Explain anaesthesia, analgesia and euthanasia
- Account for the principles of experimental surgery
- Describe pharmaceutical development and GLP
- Account for the planning, execution and publication of experimental animal studies
- Account for the alternatives to animal studies
- Explain experimental and humane endpoints
- Practical exercises