SLVKB0351U  Principles of Pharmacology

Volume 2015/2016
Education

MSc in Pharmaceutical Sciences - compulsory
MSc - elective

Content

The course deals with the following topics:

  • Neurotransmitter systems and neuropharmacology
  • Fundamental nerve/muscle/cell physiology with special focus on membrane physiology and synaptic mechanisms
  • Receptor pharmacology including receptor classifications, agonists, antagonists, development of tolerance, and analysis of receptor-ligand interactions

  • Pharmacodynamics: Dose-response relationships, dose/time relationships, use of biological systems to estimate activities of drugs, statistical analysis of biological data

  • Pharmacokinetics: General kinetics, absorption, distribution, elimination, metabolism, excretion and drug interactions

  • Drug development methods: Animal models, preclinical development and concepts of toxicology

Learning Outcome
  1. At the end of the course, students are expected to be able to:

 

Knowledge

  • Students will obtain a fundamental understanding and knowledge of the basic concepts of pharmacology and the related human physiology.

 

Skills

  1.  
  • calculate pharmacokinetic parameters of a drug from plasma concentrations time-course
  • understand the different mechanisms of action of antagonists
  • interpret antagonist pharmacological data to determine mechanism of action
  • propose experiments to distinguish antagonist mechanism of action
  • have a basic understanding of neurotransmission and neurotransmitter systems in the CNS
  • have an understanding of drug toxicity and adverse effects
  • have an understanding of clinical trials and drug monitoring

 

Competences

  1.  
  • Understand concepts used in physiology and basic pharmacology.
  • Calculate, estimate and discuss physiological and pharmacological parameters obtained from experimental and clinical data (pharmacodynamic and pharmacokinetic data).
  • Discuss and explain pharmacology-related procedures and methods used in preclinical drug development.
  • Effectively communicate pharmacological and drug information to others within the fields of pharmaceutical sciences and health sciences
  • Silverthorn: Human Physiology, 6th edition, Pearson International, 2014.
  • Rang, H.P., Dale, M.M., Ritter, J.M. & Flower, R. J.: Pharmacology, 7th edition, Churchill Livingstone, 2012.
  • Rowland, M. & Tozer, T.N.: Clinical Pharmacokinetics and Pharmacodynamics. Concepts and Applications. 4th edition, Lippincott, Williams & Wilkins, 2011.
  • Meldgaard Lund, T. and Sheykhzade M., FARMA, KU: Pharmacokinetic and -dynamic Equations and Preconditions (on the homepage).
  • Sheykhzade and Pickering: Pharmacodynamic theory notes, 9th ed, 2013 (on the homepage).
Course teaching is based on the assumption that students have passed exams in chemistry subjects corresponding to at least 15 ECTS credits, of which 10 ECTS credits should be in organic chemistry and biology, and 15 ECTS credits in biochemistry and/or molecular biology and/or microbiology.
• 30 lectures
• 19 hr of tutorial lessons
• 4 hours of laboratory work
• 1 project presentation (group work)
This course is not available to students who have previously passed an introductory pharmacology lecture course, such as: almen farmakologi (SFABB0251U) or grundlæggende farmakologi (SFABB1011U).
Credit
7,5 ECTS
Type of assessment
Written examination, 3 hours under invigilation
Project presentations will count for 10% of the final course grade and the course examination will count for 90% of the final course grade.

Exam assessment is based on a written, closed-book exam with usually 3 or 4 different assignments, each with subparts. The individual weighting of each assignment will be clearly stated on the exam paper.

The highest number of exam points achievable is 100 and the pass requirement is 50 points. Overall impression forms part of the exam assessment and may cause the score to be adjusted by up to 10%. The adjustment is based on the demonstration of an overall understanding of basic pharmacological principles and topics and the absence of major weaknesses.
Aid

No aids are allowed

Refer to the IT exams homepage link where the standard programs and IT tools available for the students’ disposal during IT exams under The Faculty of Health and Medical Sciences are listed.

Marking scale
7-point grading scale
Censorship form
External censorship
Criteria for exam assesment

To achieve the grade 12 the student must be able to:


 Knowledge

  • understand the relevant terms, principles and methods used in physiology and pharmacology.
  • Refere fundamental understanding and knowledge of the basic concepts of pharmacology and the related human physiology.
  • have a basic understanding of neurotransmission and neurotransmitter systems in the CNS
  • have an understanding of drug toxicity and adverse effects
  • have an understanding of clinical trials and drug monitoring
  • Understand concepts used in physiology and basic pharmacology.

 

Skills

  1.  
  • calculate pharmacokinetic parameters of a drug from plasma concentrations time-course
  • understand the different mechanisms of action of antagonists
  • interpret antagonist pharmacological data to determine mechanism of action
  • propose experiments to distinguish antagonist mechanism of action

 

Competences

  1.  
  • Calculate, estimate and discuss physiological and pharmacological parameters obtained from experimental and clinical data (pharmacodynamic and pharmacokinetic data).
  • Discuss and explain pharmacology-related procedures and methods used in preclinical drug development.
  • Effectively communicate pharmacological and drug information to others within the fields of pharmaceutical sciences and health sciences
  • Category
  • Hours
  • Lectures
  • 30
  • Preparation
  • 60
  • Project work
  • 20
  • Class Instruction
  • 38
  • Exercises
  • 6
  • Preparation
  • 2
  • Exam Preparation
  • 50
  • Total
  • 206