SLVKA0361U  Pharmaceutical Analytical Chemistry

Volume 2015/2016
Education

MSc in Pharmaceutical Sciences - compulsory for line 2

MSc in Medicinal Chemistry - elective

Content

Study groups and exercises constitute an integrated course package. The course provides a background for selecting and developing analytical methods and assessing the reliability of analytical data. A variety of analytical techniques are described with regard to their use in quantitative determination and identification. Teaching will focus on the design and use of apparatus as well as potential sources of error. There will also be focus on quality assurance and validation of analytical methods, including the significance of linearity, accuracy, precision, sensitivity, determination limits, blind values, selectivity and interference. Study groups are used to discuss theoretical background. The students take turns giving 30-minute presentations on theoretical subjects, which are subsequently discussed and related to the practical experiments. In the practical exercises, students work with fixed demonstrations of separation and detection methods. They simultaneously work on a project where they plan and try out a number of these techniques on a given drug. The analytical techniques are liquid chromatography (HPLC), gas chromatography (GC), capillary electrophoresis (CE), UV-VIS spectrophotometry, fluorometry, mass spectrometry (MS), atomic absorption spectrometry (AAS) and potentiometric methods. The students carry out experiments in groups and submit a joint report. Reports are assessed by the teacher and discussed on return.

Learning Outcome

Objective

To enable students to develop and use analytical chemical methods in connection with development of drug substances, as well as identification and quality assessment of drugs and excipients.
 

At the end of the course, students should be able to:

Knowledge

  • explain the principle of the techniques, their areas of application and potential sources of error

  • understand the methodological terminology required for reading literature and writing reports

  • assess the reliability of analytical data

  • report experiments briefly, clearly and unambiguously.

Skills

  • Identify quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied

 

Competences

  • Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods

  • D.C. Harris: Quantitative Chemical Analysis, latest edition, W.H. Freeman and Company, New York.
  • Compendium in Pharmaceutical Analytical Chemistry, latest edition, Department of Pharmacy, University of Copenhagen. Is available on the course home page via Absalon.
Students must have accumulated at least 15 ECTS credits in chemical subjects, of which 10 ETCS credits must be in the field of organic chemistry.
•Exercises/project: 16 four-hour sessions plus report writing
•Study groups: 8 two-hour sessions
Credit
7,5 ECTS
Type of assessment
Oral examination under invigilation
Individual oral examination based on reports from the laboratory exercises.

Examination design:
Individual oral exam with preparation time. The student is examined on the basis of two reports selected by lot. After the report selection, the student has 30 minutes’ preparation time.
Exam registration requirements

Registration for the exam is contingent on approval of all reports from the laboratory exercises.

Aid

All written aids allowed.

Marking scale
7-point grading scale
Censorship form
External censorship
Criteria for exam assesment

To achieve the grade 12 the student must be able to:

Knowledge

  • explain the principle of the techniques, their areas of application and potential sources of error

  • understand the methodological terminology required for reading literature and writing reports

  • assess the reliability of analytical data

  • report experiments briefly, clearly and unambiguously.

Skills

  • Identify quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied
  • describe the analytical methods applied in the selected reports and demonstrate ability to perform quantitative determinations based on analytical data.

 

Competences

  • Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods

  • Category
  • Hours
  • Colloquia
  • 6
  • Preparation
  • 39
  • Practical exercises
  • 55
  • Project work
  • 106
  • Total
  • 206