NKEK13007U Reactions and Synthesis in Medicinal Chemistry (KemiMed)

Volume 2015/2016

MSc Programme in Chemistry
MSc Programme in Medicinal Chemistry


The topics are: Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems.

Learning Outcome


Be able to analyze a complex synthetic problem and plan a feasible synthesis.
Be able to analyze scientific papers and patents dealing with synthetic problems and be able to spot inconsistent claims.

Apply the aquired knowledge on organic synthesis on a given target molecule. Be able to translate known methodologies to new problems.

Have an in depth knowledge of modern synthetic organic synthesis according to the content of the course.


Will be announced on Absalon

It is expected that the students are familiar with the content of the courses KemiU1, KemiU2, KemiO, KemiBin, AnvSpek, FysKem1, FysKem2, KemiVO, OrgSyn (eller VidOrgSyn).
Lectures, problem solving in class and written take-home assignments
  • Category
  • Hours
  • Exam
  • 1
  • Lectures
  • 26
  • Preparation
  • 327
  • Theory exercises
  • 52
  • Total
  • 406
Type of assessment
Oral examination
The exam is an oral examination based on one of the take-home assignments chosen randomly (by lot).
Exam registration requirements

There will be 12 take-home assignments during the course, which will have to be approved in order to take the exam.

Marking scale
7-point grading scale
Censorship form
External censorship

The re-examination is also an oral examination based on one of the take-home assignments chosen randomly (by lot).
All missing take home assignments must be submitted no later than two weeks prior to reexam.

Criteria for exam assesment

See Learning Outcome