NBIK14006U Principles in Genomic Studies
MSc Programme in Bioinformatics
The goal of this course is to give students a thorough introduction to the types and applications of the different genomic tools available, including understanding their usability and limitations. We will introduce students to the concepts of genomic, metagenomic, and transcriptomic data acquisition and analyses, with an emphasis on organisms where little genomic data is available beforehand.
During the course the students will write an essay in the form of a grant proposal in which they formulate their own research question and describe an experimental study design using genomics to answer this question. The essay is part of the course assessment and will function as a starting point for discussion at the oral exam.
The course is directed at biology students who want to become familiar with the use of genomic data for hypothesis development and testing, and for bioinformatics and biochemistry students with an interest in applying their skills outside classic genomic model systems. Please note that this course will focus on the principles and concepts of genomic study design, not the exact analysis methods. For practical experience with the analysis of genomic data we recommend other courses, e.g. Biological Sequence Analysis or Bioinformatics of High Throughput Analysis.
Specific topics covered:
- Sequencing technologies
- Genome assembly
- Genome annotation
- Pathway reconstruction
- Comparative genomics
- RNA-seq
- CHIP-seq
- Methylomics
- Metagenomics
- Host-symbiont interactions
- Evolutionary genomics
- Ancient genomics
Knowledge:
By completing the course the student obtain knowledge of:
- Different sequencing technologies (e.g. 454, Illumina) and their applications in different "omics"-type experiments (e.g. genomics, transcriptomics, methylomics and metagenomics).
- The concepts of different analysis methods of data (e.g. assembly, annotation and expression analyses).
- The broad range of research questions that can be addressed with these techniques, e.g. within ecology, evolution, symbiosis, development and behavior.
Skills:
By completing the course the student can:
- explain the strengths and limitations of different sequencing technologies
- explain the principles behind, and limitations of, different analysis methods
- discuss and evaluate scientific literature that uses genomics-type methods
- choose suitable genomics methods to address specific biological questions.
Competences:
By completing the course the student can:
- formulate scientific hypotheses that can be investigated using genomic methods
- independently design, plan, and present experimental setups using genomic methods
- independently retrieve information to help formulate hypotheses and choose appropriate methods.
See Absalon.
- Category
- Hours
- Colloquia
- 28
- Exam Preparation
- 30
- Lectures
- 17
- Practical exercises
- 6
- Preparation
- 75
- Project work
- 50
- Total
- 206
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- Credit
- 7,5 ECTS
- Type of assessment
- Written assignmentOral examination, 25 min.A short essay written as a grant proposal, in which students choose a biological system of their own interest (e.g. an organism, a symbiosis, a disease), present a hypothesis, and explain how genomic tools and data can be used to test the hypothesis. The essay will function as a starting point for discussion in a final 25-minute oral exam. 50:50 weight of the essay and oral exam.
The essay and the oral exam must be passed separately, and the essay and the exam must be passed in the same exam period. - Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Several internal examiners
- Re-exam
- One-week take-home assignment.
Criteria for exam assesment
In order to achieve the grade 12 the students gives an excellent performance displaying a high level of command of all aspects of the relevant material, with no or only a few minor weaknesses.
Course information
- Language
- English
- Course code
- NBIK14006U
- Credit
- 7,5 ECTS
- Level
- Full Degree Master
- Duration
- 1 block
- Placement
- Block 2
- Schedule
- B
- Course capacity
- No limitation
- Continuing and further education
- Study board
- Study Board of Biology and Animal Science
Contracting department
- Department of Biology
Course responsibles
- Morten Schiøtt (8-7177676c6d73787844666d73326f7932686f)