CSU2016114 Personalised Medicine – the future treatment paradigm

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Personalised medicine is a rapidly developing and growing field. Advances in genomic and clinical science have created innovative opportunities to tailor health care to each patient. Personalised medicine is a strategy based on individual phenotyping of profiles rather than the long established ‘onesize-fits-all’ approach. It is based on a multidisciplinary approach translating advances in basic science and drug discovery and development into clinical practice.

It has wide implications for public health, preventive interventions and for the rational design of screening programmes. The collaboration between disciplines is reflected in the curriculum of the present course, which is of relevance for persons engaged in research, clinical medicine, the pharmaceutical industry as well as those involved in health care administration and politics.

Short introduction from the course directors
Personalised medicine identifies elements that predict the individuals’ predisposition to disease and their response to treatment. The relatively new tools and methods of personalised medicine integrate genomic information with clinical and custom laboratory data, which enables classification of unique disease sceptibility, better diagnoses, earlier interventions, targeted and more efficient drug therapies and customized treatment.

What you will learn
After the course you will have acquired:

• An overview of the toolbox of personalised medicine.
• An understanding of challenges and pitfalls in the analyses and interpretation of “big data”.
• Knowledge on the practical translation of research findings into clinical practise.
• An understanding of genomics, epigenomics and pharmacogenenomics and how these have been or can be implemented in clinical medicine.
• Insight into how principles of personalised medicine have been used to develop drugs and change treatment regimens to target therapy and improve outcomes.
• Insight into the future perspectives of personalised medicine.

Course content
This course will provide insights into key principles and give a practical understanding of the concept of personalised medicine. The course will take you through important aspects of the strategy of personalised medicine from an overview of methodological principles, advances in research and application of these into daily clinical practice of medicine and drug development and we will discuss economic implications as well as ethical aspects. The teaching style is interactive and includes a combination of lectures, discussions, group work and case studies/exercises.

The topics include:

• Individual phenotyping
• Genomic medicine
• Epigenetics
• Pharmacogenomics
• Use of “big data” to develop a concept of personalised medicine
• Imaging in personalised medicine
• Using already developed medicines as part of a personalised medicine concept
• Novel drug discoveries aimed for personalised medicine
• Devises for personalised medicine
• The role of personalized medicine in research, prevention and tailored treatment of:
  • Diabetes
  • Cardiovascular disease
  • Cancer
  • Immune deficiency & Transplantation
• Private-public partnerships
• The perspectives of politicians, health care administrators and patient organisations on personalised medicine
• Personalised medicine and health economics
• Future perspectives of personalised medicine – in 10, 20 and 30 years.

Participants
The course is for professionals working in the field of medicine, bioinformatics or related health sciences (e.g. public health, humane biology and biotechnology),
persons with special interest in technical aspects of health and medicine and persons from the pharmaceutical industry. It will also be of interest to those working in ministerial departments and the regions.

The course offers an excellent introduction for those less familiar with the concept of personalised medicine and will provide a deeper understanding for health professionals with experience within the field. Participants must hold at least a relevant bachelor
degree or equivalent.

Course dates
5 days, 22 – 26 August 2016, 9:00 – 16:30 at the University of Copenhagen, Frederiksberg Campus.

Course directors
Marie Helleberg, MD, PhD, DMSc, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen
Jens Lundgren, Professor, DMSci, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen

Other course teachers
Ulrik Lassen, Consultant, PhD, Phase 1 Unit, Department of Oncology, Copenhagen University Hospital, Rigshospitalet
Kirsten Grønbæk, Professor, DMSci, Department of Haematology, Copenhagen University Hospital, Rigshospitalet
Finn Cilius Nielsen, Professor, Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet
Henning Bundgaard, Professor, DMSci, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet
Søren Brunak, Professor, Dr.Phil., Department of Systems Biology, Technical University of Denmark
Torben Jørgensen, Professor, DMSci, University of Copenhagen
Henrik Sengeløv, DMSci, Department of Hematology, Copenhagen University Hospital, Rigshospitalet
Torben Franck Ørntoft, Professor, Head of Department of Molecular Medicine, Aarhus University Hospital
Gunna Christensen, Professor, Department of Biomedicine, Aarhus University
Niles Grarup, Ass. Professor, Section for Metabolic Genetics, Dep. of Computer Science, University of Copenhagen
Barbara Malene Fischer, Assoc. Professor, Dep. of Clinical Physiology, Copenhagen University Hospital, Rigshospitalet
Nils Brünner, Professor, Department of Veterinary Disease Biology,
Section Molecular Disease Biology, University of Copenhagen

Course fee
EUR 2,600/DKK 19,000 (excl. Danish VAT 25%). Fee includes teaching, course materials and all meals during the course.

Approved by the Organisation of General Practitioners in Denmark
If you are a member of the Organisation of General Practitioners in Denmark (PLO) you can apply for reimbursement.