NBIA04055U Advanced Bacteriology
Contents:
Week 1: Bacterial interactions
- Bacterial interactions
- Quorum sensing
- Socio-microbiology
Week 2: Microbial biofilm and evolution
- Biofilms
- Evolution of bacteria
- Bioinformatic analysis
Week 3: Bacterial mobile genetic elements
- Mobile genetic elements: Plasmids, transposons, and
bacteriophages
- Integrons and transposons
- Horizontal transfer of plasmids in natural environments
Week 4: Bacterial physiology and identification
- Identification and detection of bacteria
- Structure and function of the prokaryotic cell
- Metabolic diversity
Week 5: Symbiotic and pathogenic bacteria
- Bacterial symbionts in animals
- Bacterial inhabitants of humans
Week 6: Bacterial disease mechanisms
- Bacterial disease mechanisms
- Infectious biology in humans of selected bacteria
- From free-living to pathogen: Adaptation to pathogenicity
Week 7: Human bacterial pathogens
- Disease and bacteria in the human intestine
- Gastrointestinal diseases
- Bacterial pathogens with different life styles
Knowledge:
- Understanding of structural and functional attributes of bacteria that relate to their ability to live as single-cell organisms or in intimate associations with eukaryotes
- Understanding of the metabolic diversity of bacteria and the diversity in an ecological context
- Detailed knowledge on the different mechanisms behind horizontal gene transfer among bacteria
- Understanding of the prokaryotic species concept and evaluate different species definitions
- Understanding of the molecular basis of bacterial mutualistic symbiosis with a selection of animals
- Knowledge on selected bacterial inhabitants of humans and their physiology in relation to their habitat
- Detailed knowledge on the mechanisms of bacterial pathogenesis in humans
- describe in detail the molecular basis of pathogenesis of selected pathogenic bacteria on humans
Skills:
The student will be able to;
- evaluate the importance of biofilm formation to bacterial survival
- evaluate quorum sensing in relation to biofilm formation, bacterial physiology, and bacterial pathogenesis
- evaluate the concept of sociomicrobiology and analyse the importance of bacterial interactions
- analyse the evolution and phylogeny of bacteria
- analyse horizontal transfer of plasmids in natural environments
- evaluate methods for detection, identification and subtyping of bacteria
- evaluate and analyse bacterial adaptations to pathogenicity
- evaluate the potential of bacteria to produce infectious disease in humans
Competencies:
The student will be able to;
- use and evaluate molecular methods to investigate bacterial biofilm formation and horizontal gene transfer among bacteria, and analyse subsequent data
- discuss plasmid replication, plasmid maintenance and plasmid copy number regulation in bacteria
- put into a plasmid perspective the evolution of antibiotic resistance, both in human infections and in various environments
- analyse, put into perspective, and criticize the primary scientific literature
- perform effective written and oral presentation of acquired knowledge and ideas
See Absalon.
- Category
- Hours
- Colloquia
- 42
- Exam
- 1
- Lectures
- 35
- Practical exercises
- 28
- Preparation
- 266
- Project work
- 40
- Total
- 412
As
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Continuing Education - click here!
- Credit
- 15 ECTS
- Type of assessment
- Practical written examinationPractical oral examinationGrading by the 7-step scale is based on essay (in groups) on the practicals (25% of final grade) and final oral exam (75% of final grade) based on curriculum and practicals with external censorship.
Reexam will be held as the ordinary exam. - Exam registration requirements
- In order to be allowed to the final exam, the student should have participated actively in the course by being present at the exercises (minimum 80% presence at the exercises), and by performing a satisfactory oral presentation based on a scientific paper.
- Marking scale
- 7-point grading scale
- Censorship form
- External censorship
Criteria for exam assesment
To achieve the grade 12 the student must be able to:
- describe the structural and functional attributes of bacteria that relate to their ability to live as single-cell organisms or in intimate associations with eukaryotes
- describe the metabolic diversity of bacteria and explain the diversity in an ecological context
- describe in detail the different mechanisms behind horizontal gene transfer among bacteria and evaluate their importance to bacterial survival and evolution
- describe the prokaryotic species concept and evaluate different species definitions
- describe the molecular basis of bacterial mutualistic symbiosis with a selection of animals
- describe a selection of bacterial inhabitants of humans and evaluate their physiology in relation to their habitat
- evaluate the importance of biofilm formation to bacterial survival
- evaluate quorum sensing in relation to biofilm formation, bacterial physiology, and bacterial pathogenesis
- evaluate the concept of sociomicrobiology and analyse the importance of bacterial interactions
- analyse the evolution and phylogeny of bacteria
- analyse horizontal transfer of plasmids in natural environments
- evaluate methods for detection, identification and subtyping of bacteria
- evaluate and analyse bacterial adaptations to pathogenicity
- use and evaluate molecular methods to investigate bacterial biofilm formation and horizontal gene transfer among bacteria, and analyse subsequent data
- discuss plasmid replication, plasmid maintenance and plasmid copy number regulation in bacteria
- put into a plasmid perspective the evolution of antibiotic resistance, both in human infections and in various environments
- analyse, put into perspective, and criticize the primary scientific literature
- perform effective written and oral presentation of acquired knowledge and ideas
Course information
- Language
- English
- Course code
- NBIA04055U
- Credit
- 15 ECTS
- Level
- Full Degree Master
- Duration
- 1 block
- Placement
- Block 1
- Schedule
- Outside schedule
- Continuing and further education
- Study board
- Study Board of Biology and Animal Science
Contracting department
- Department of Biology
Course responsibles
- Søren Johannes Sørensen (3-7a717a4769707635727c356b72)
Lecturers
Mette Burmølle, Niels-Ulrik Frigaard, Lars H. Hansen, Michael Kühl, Anders Priemé og gæsteforelæsere.