SMOA09011U Theoretical Pathophysiologiy

Volume 2013/2014
Education
MSc Programme in Molecular Biomedicine - compulsory
Content
This candidate course focuses on a theoretical approach to the study of the genetic, molecular and physiological mechanisms underlying a variety of common diseases. Focused lectures and background text-book reading will provide current knowledge and research approaches towards understanding pathways underlying altered physiological function in various disease states. In addition to reading basic text-book chapters, research-based scientific lectures will lead to the formulation of a solid knowledge foundation on current theories, disease etiology and pathophysiological manifestations. Each topical lecture will be structured to cover several levels of organization where appropriate including integration of gene signalling and cellular signaling cascades into organ and systemic physiological function. A major emphasis for the course is for students to approach the study of pathologies on the basis of ‘function’ (pathophysiology) including altered structure-function relationships and the associated regulatory processes. Students are expected to engage in independent critical reading of the assigned text. Students are encouraged to attend all lectures and participate in discussion with faculty on the topics listed in the course schema. Focused study on all course topics will prepare students for a formal written essay exam which will comprise the evaluation of the extent and depth of learning and thus the basis for their grade in the course.
Learning Outcome

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26 lectures. Basic-to-cutting edge concepts on the pathophysiology of major diseases will be covered by experts in the field with a focus on integrative molecular pathophysiology. The lecture content will take its basis in basic knowledge covered in the course text and unfold new and prospective avenues of basic science and clinical research that elucidate the pathophysiology of common disease.
Topics: 1. Introduction to the course - cellular pathophysiology
2. Introduction to the course - integrative pathophysiology
3. Circulatory physiology and heart failure
4. Blood pressure homeostasis and hypertension
5. Respiratory physiology
6. Chronic obstructive pulmonary diseases
7. Kidney physiology and calcium homeostasis
8. Glomerular and tubular kidney diseases
9. Inflammation
10. Atherogenesis and iscaemic heart disease
11. Haematopoiesis
12. Anemias
13. Carcinogenesis
14. Metastasis
15. Liver physiology and hepatic cirrhosis
16. Acid scretion and gastric ulcer
17. Insulin secretion and action
18. Type 1 diabetes pathophysiology
19. Type 2 diabetes pathophysiology
20. Pathophysiology of late diabetic complications
21. Autoimmunity and reumatoid arthritis
22. Osteoarthritis
23. Osteoporosis
24. HIV/Acquired immunodeficiency
25. Degenerative neurological diseases
26. Information on the written exam format
  • Category
  • Hours
  • Exam
  • 4
  • Lectures
  • 26
  • Preparation
  • 176
  • Total
  • 206
Credit
7,5 ECTS
Type of assessment
Written examination, 4 hours under invigilation
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Marking scale
7-point grading scale
Censorship form
No external censorship
More than one internal examiner
Exam period
Week 45, 2014
Criteria for exam assesment

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