of cardiac physiology: The genesis and propagation of the cardiac
action potential; the molecular components underlying the different
cardiac ionic currents; regulation of these components in health
and disease; excitation-contraction coupling and cardiac output;
ECG; human cardiac diseases, including arrhythmias and heart
failure; pharmacotherapy; animal models; drug discovery and
cardiovascular safety. The practical exercises will provide the
student with hands on experience concerning cardiac experimentation
in respect to fully functional explanted hearts and multicellular
cardiac tissue strips.
offer students a thorough understanding of cardiac physiology and
pathophysiology. Students will gain a detailed perception of
pacemaking and of action potential propagation and termination in
the different parts of the heart. The delicate ionic balance
responsible for adjusting the action potential morphology, as well
as several of the parameters influencing this balance, including
parasympathetic and sympathetic stimulation, will become clear.
Following this course, students will understand the link between
calcium handling, excitation-contraction coupling, and pumping
efficiency. The causal connection between molecular regulation,
protein function, and physiological performance will be evident.
Finally, an outline of the patho-physiological and -molecular
mechanisms underlying several different cardiac diseases will be
known after completion of this course.