SFKKA9061U Advanced Drug Delivery

Volume 2013/2014
Education
MSc in Pharmaceutical Sciences - elective, MSc in Medicinal Chemistry - elective, Cand.Scient.Pharm. - elective, Cand.Pharm. - elective
Content
Pharmaceutical aspects of modern drug delivery systems as well as alternative application sites with a view to optimising therapeutic effect.Selected modern formulation principles (applied as well as potential) will be dealt with theoretically and methodically to shed light on problems/issues concerning the optimisation of absorption, selective transport and targeting as well as the properties and effect of excipients.The following topics will be covered:
  1. drug classes (small molecules, prodrugs, peptides, proteins, nucleotides, etc.); applicable delivery systems (solid dispersions, self-emulsifying systems, cyclodextrins, nanoparticles, liposomes, etc.) and administration routes (oral, IV, IM, topical, pulmonary, nasal, etc.).
  2. development and characterisation of drug delivery systems.
  3. release, transport and absorption studies in in vitro and in vivo models.
  4. experimental work covering
    • in vitrocell models of drug absorption
    • development and characterisation of nanoparticulate systems (eg. liposomes and polymeric nanoparticles)
    • development and characterisation of oral delivery systems for poorly soluble drugs (eg. self-emulsifying drug delivery systems and solid dispersions) including drug release and absorption studies.
Learning Outcome

Formål / Objective

To give students a theoretical and experimental background for evaluating selected, recently developed advanced drug delivery principles as well as the ability to critically evaluate the relevant literature. Emphasis is also on presenting and discussing scientific literature.

Målbeskrivelse / Course outcome

At the end of the course, students should be able to:
  1. give an account of selected advanced drug delivery systems e.g. liposomes, SMEDDS, nanoparticles and stabilised amorphous forms, including their areas of application
  2. give an account of important physiological mechanisms and kinetics related to ADME, as well as methods used to characterize ADME, in vitro and in vivo
  3. evaluate scientific literature related to advanced drug delivery
  4. demonstrate thorough understanding of the laboratory experiments included in the course.
Scientific articles available from the course website.
A bachelor’s degree in pharmaceutical sciences or the equivalent.
•Lectures: 28 hours
•Laboratory exercises: 24 hours
•Final seminar with poster presentation: 7 hours
  • Category
  • Hours
  • Exam
  • 7
  • Lectures
  • 28
  • Practical exercises
  • 24
  • Preparation
  • 147
  • Total
  • 206
Credit
7,5 ECTS
Type of assessment
Course participation
Written assignment
Course assessment is based on the student’s participation, understood to mean:
•that the student has satisfactorily carried out and written reports on the experimental parts of the course
•that in a group with 2-3 others the student has prepared a poster on the basis of a peer-reviewed article and presented and discussed the poster at the final seminar.
Marking scale
passed/not passed
Censorship form
No external censorship
Criteria for exam assesment
Course assessment is based on the student’s participation, understood to mean:
•that the student has satisfactorily carried out and written reports on the experimental parts of the course
•that in a group with 2-3 others the student has prepared a poster on the basis of a peer-reviewed article and presented and discussed the poster at the final seminar.