NBIK10015U Cell Cycle Control and Cancer

Volume 2013/2014
Education
MSc Programme in Molecular Biomedicine
Content
To give students a thorough understanding of pioneering and contemporary cell cycle research with emphasis on the mechanisms that are deregulated in cancer.

To be able to understand, evaluate and convey molecular genetic research on cell cycle control and cancer development.

In 2011 the course was organised in the following themes:
  • Cancer as a genetic disease
  • Basic cell-cycle regulation and deregulation of the pRB pathway
  • p53 and checkpoints
  • Genetic instability and DNA repair
  • Cancer and differentiation
  • Loss of heterozygousity
  • Epigenetics and cancer
  • Mechanisms of chromosome mis-segregation
  • Apoptosis
This list may be subject to minor modifications in 2012.
within each course week one or two themes will be covered by an introductory lecture, by group discussions of papers (journal-club format) and by a research seminar given by an expert in the field.
Learning Outcome
Knowledge:
A critical experimental approach applied to the study of cell cycle control. The course is heavy on genetics, but also deals with techniques of cell biology, protein chemistry and biochemistry.

Skills:
The student will be able to read, understand and convey the reasoning and logic of scientific experiments that deals with experimental approaches to cell cycle control in normal cells, and the genetic deregulation of theses control mechanisms that causes cancer or contribute to cancer development.


Competencies:
To be able to understand, evaluate and convey molecular genetic research on cell cycle control and cancer development.
Literature
See Absalon.
Molecular Genetics or equivalent.
Lectures, group discussions of research papers, and guest seminars.
  • Category
  • Hours
  • Exam
  • 4
  • Lectures
  • 27
  • Preparation
  • 148
  • Theory exercises
  • 27
  • Total
  • 206
Credit
7,5 ECTS
Type of assessment
Written examination, 4 hours under invigilation
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Marking scale
7-point grading scale
Censorship form
No external censorship
Criteria for exam assesment
The exam evaluate the ability to draw scientific conclusions on experimental data taken from scientific publications.

The grade 12 is given for outstanding performance demonstrating complete fulfillment of the under "Learning Outcome" described, with no or few minor weaknesses.