SMTB20003U Course in Modelling of Physiological Systems
BSc programme in Medicine and Technology (Biomedical Engineering) (valgfrit kursus)
The goal of the course is to enable the students to understand and handle tools for biosimulation and to apply mathematical modeling in biomedical sciences. The course is focused on dynamical aspects of regulatory mechanisms at different levels of biological organization, i. e. cellular and systems physiology.
At the end of the course the student is expected to be able to:
Knowledge
Explain different approaches to modeling
Understand mathematical/physics concepts (dynamical systems, stability analysis, oscillations, synchronization)
Understand simple computational algorithms used for modeling
Explain main models and dynamics of excitable cells
Explain mechanisms and mathematical description of calcium dynamics
Understand mechanisms of insulin-glucose regulation and mathematical description of involved feedback loops
Understand mechanisms and mathematical description of vascular responses and kidney autoregulation
Understand regulatory mechanisms of circadian rhythms and their simple mathematical models
Skills
Discuss modeling approaches depending on the purpose of study
Apply mathematical/physical concept to particular biomedical problem
Formulate model of excitable cells and discuss their possible simplifications and dynamics
Formulate a simple model for calcium oscillations and discuss possible dynamics
Formulate a model of insulin absorption and insulin-glucose regulation, perform analysis of the observed phenomena and discuss their relevance to diabetes
Formulate a model for kidney autoregulation, perform analysis of the observed phenomena and discuss their relevance to hypertension
Discuss applications of chronobiology and formulate a simple model of circadian rhythms
Reproduce, modify and simulate models from scientific literature
- Improve scientific and academic vocabulary of English language
Competence
To formulate mechanism-based models and find appropriate methods to investigate them
To interpret dynamical features of biomedical systems from biological and mathematical points of view
To integrate fundamental knowledge from physics, mathematics and biology to provide better understanding of regulatory mechanisms
On-line lectures and lecture notes
- Category
- Hours
- Lectures
- 24
- Preparation
- 65,2
- Theory exercises
- 24
- E-Learning
- 24
- Exam
- 0,3
- Total
- 137,5
Campusnet DTU
Open for credit transfer students and other external students. Apply here:
Credit transfer students:
Credit transfer student at SUND – University of Copenhagen (ku.dk)
Other external students:
http://healthsciences.ku.dk/education/exchange_guest_students/guest-students/
- Credit
- 2,5 ECTS
- Type of assessment
- Requirement to attend classes
- Type of assessment details
- Participation in exercises and approval of reports
- Aid
- All aids allowed
- Marking scale
- passed/not passed
- Censorship form
- No external censorship
An internal examiner
Criteria for exam assesment
To obtain the course certificate the student must be able to
Knowledge
Explain different approaches to modeling
Understand mathematical/physics concepts (dynamical systems, stability analysis, oscillations, synchronization)
Understand simple computational algorithms used for modeling
Explain main models and dynamics of excitable cells
Explain mechanisms and mathematical description of calcium dynamics
Understand mechanisms of insulin-glucose regulation and mathematical description of involved feedback loops
Understand mechanisms and mathematical description of vascular responses and kidney autoregulation
Understand regulatory mechanisms of circadian rhythms and their simple mathematical models
Skills
Discuss modeling approachesdepending on the purpose of study
Apply mathematical/physical concept to particular biomedical problem
Formulate model of excitable cells and discuss their possible simplifications and dynamics
Formulate a simple model for calcium oscillations and discuss possible dynamics
Formulate a model of insulin absorption and insulin-glucose regulation, perform analysis of the observed phenomena and discuss their relevance to diabetes
Formulate a model for kidney autoregulation, perform analysis of the observed phenomena and discuss their relevance to hypertension
Discuss applications of chronobiology and formulate a simple model of circadian rhythms
Reproduce, modify and simulate models from scientific literature
- Improve scientific and academic vocabulary of English language
Competence
To formulate mechanism-based models and find appropriate methods to investigate them
To interpret dynamical features ofbiomedical systems from biological and mathematical points of view
To integrate fundamental knowledge from physics, mathematics and biology to provide better understanding of regulatory mechanisms
- Credit
- 2,5 ECTS
- Type of assessment
- Oral examination, 25 minutter
- Type of assessment details
- Oral exam, without preparation
- Exam registration requirements
Course certificate in Modelling of Physiological Systems (SMTB20003E)
- Aid
- Without aids
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Several internal examiners
- Exam period
Please visit: http://sund.ku.dk/uddannelse/vejledning-information/eksamensplaner/
- Re-exam
Please visit: http://sund.ku.dk/uddannelse/vejledning-information/eksamensplaner/
Criteria for exam assesment
To obtain the grade 12, the student must be able to
Knowledge
Explain different approaches to modeling
Understand mathematical/physics concepts (dynamical systems, stability analysis, oscillations, synchronization)
Understand simple computational algorithms used for modeling
Explain main models and dynamics of excitable cells
Explain mechanisms and mathematical description of calcium dynamics
Understand mechanisms of insulin-glucose regulation and mathematical description of involved feedback loops
Understand mechanisms and mathematical description of vascular responses and kidney autoregulation
Understand regulatory mechanisms of circadian rhythms and their simple mathematical models
Skills
Discuss modeling approachesdepending on the purpose of study
Apply mathematical/physical concept to particular biomedical problem
Formulate model of excitable cells and discuss their possible simplifications and dynamics
Formulate a simple model for calcium oscillations and discuss possible dynamics
Formulate a model of insulin absorption and insulin-glucose regulation, perform analysis of the observed phenomena and discuss their relevance to diabetes
Formulate a model for kidney autoregulation, perform analysis of the observed phenomena and discuss their relevance to hypertension
Discuss applications of chronobiology and formulate a simple model of circadian rhythms
Reproduce, modify and simulate models from scientific literature
- Improve scientific and academic vocabulary of English language
Competence
To formulate mechanism-based models and find appropriate methods to investigate them
To interpret dynamical features of biomedical systems from biological and mathematical points of view
To integrate fundamental knowledge from physics, mathematics and biology to provide better understanding of regulatory mechanisms
Course information
- Language
- English
- Course code
- SMTB20003U
- Credit
- See exam description
- Level
- Bachelor
- Duration
- 1 semester
- Placement
- Autumn
- Schedule
- Mandag i tidsrummet 13-17/Mondays between 13-17
- Course capacity
- 60 students
Study board
- Study board from DTU
Contracting department
- Department of Biomedical Sciences
Contracting faculty
- Faculty of Health and Medical Sciences
Course Coordinators
- Olga Sosnovtseva (4-76736e68477a7c756b35727c356b72)
Spørgsmål til undervisning eller holdsætning på dine KU-kurser, kontakt:
Undervisning@sund.ku.dk
Spørgsmål til og examiner på dine KU-kurser, kontakt:
eksamen@sund.ku.dk
Spørgsmål til studieplanlægning på SUND, kontakt:
vejledning@sund.ku.dk