SFKKA9061U Advanced Drug Delivery
MSc in Pharmaceutical Sciences - elective, MSc in Medicinal Chemistry - elective, Cand.Scient.Pharm. - elective, Cand.Pharm. - elective
Pharmaceutical aspects of modern drug delivery systems as well as alternative application sites with a view to optimising therapeutic effect. Selected modern formulation principles (applied as well as potential) will be dealt with theoretically and methodically to shed light on problems/issues concerning the optimisation of absorption, selective transport and targeting as well as the properties and effect of excipients. The following topics will be covered:
- drug classes (small molecules, prodrugs, peptides, proteins, nucleotides, etc.); applicable delivery systems (solid dispersions, self-emulsifying systems, cyclodextrins, nanoparticles, liposomes, etc.) and administration routes (oral, IV, IM, topical, pulmonary, nasal, etc.).
- development and characterisation of drug delivery systems.
- release, transport and absorption studies in in vitro and in vivo models.
- experimental work covering
- in vitro cell models of drug absorption
- development and characterisation of nanoparticulate systems (eg. liposomes and polymeric nanoparticles)
- development and characterisation of oral delivery systems for poorly soluble drugs (eg. self-emulsifying drug delivery systems and solid dispersions) including drug release and absorption studies.
To give students a theoretical and experimental background for
evaluating selected, recently developed advanced drug delivery
principles as well as the ability to critically evaluate the
relevant literature. Emphasis is also on presenting and discussing
scientific literature.
At the end of the course, students should be able to:
Knowledge
- give an account of selected advanced drug delivery systems e.g. liposomes, SMEDDS, nanoparticles and stabilised amorphous forms, including their areas of application
- give an account of important physiological mechanisms and kinetics related to ADME, as well as methods used to characterize ADME, in vitro and in vivo
Skills
- evaluate scientific literature related to advanced drug delivery
- demonstrate thorough understanding of the laboratory experiments included in the course.
Scientific articles available from the course website.
•Laboratory exercises: 24 hours
•Final seminar with poster presentation: 7 hours
- Category
- Hours
- Exam
- 7
- Lectures
- 28
- Practical exercises
- 24
- Preparation
- 147
- Total
- 206
Open for Danish and international guest students. For application details look here: http://sund.ku.dk/uddannelse/andre-uddannelsestilbud/meritstuderende/.
- Credit
- 7,5 ECTS
- Type of assessment
- Course participationWritten assignmentA course certificate is completed on the basis of the student’s participation, understood to mean:
•that the student has satisfactorily carried out and written reports on the experimental parts of the course
•that in a group with 2-3 others the student has prepared a poster on the basis of a peer-reviewed article and presented and discussed the poster at the final seminar. - Marking scale
- passed/not passed
- Censorship form
- No external censorship
Criteria for exam assesment
To pass the course the student must be able to:
Knowledge
- give an account of selected advanced drug delivery systems e.g. liposomes, SMEDDS, nanoparticles and stabilised amorphous forms, including their areas of application
- present and discuss scientific literature.
Skills
- evaluate scientific literature related to advanced drug delivery
- evaluate selected, recently developed advanced drug delivery principles
- analyse laboratory experiments included in the course.
Competence
- give an account of important physiological mechanisms and kinetics related to ADME, and assess methods used to characterize ADME, in vitro and in vivo
Course information
- Language
- English
- Course code
- SFKKA9061U
- Credit
- 7,5 ECTS
- Level
- Full Degree MasterFull Degree Master choice
- Duration
- 1 block
- Placement
- Block 2
- Schedule
- C
- Course capacity
- 36 students
- Study board
- Study Board of Pharmaceutical Sciences
Contracting department
- Department of Pharmacy
Course responsibles
- Anette Müllertz (15-6e7b728181723b7a827979727f81874d80827b713b78823b7178)