SFKK18006U  Biopharmaceutics: Aspects of Drug Delivery System Design

Volume 2018/2019
Education

MSc Programme in Pharmacy or Pharmaceutical Sciences (Danish programmes cand.pharm and cand.scient.pharm) - elective

MSc Programme in Medicinal Chemistry - elective

MSc Programme in Pharmaceutical Sciences (English programme) - elective

Content

The course addresses in detail the aspects of biopharmaceutics in drug delivery.

This includes consideration of not only the drugability of a specific drug molecule for reaching a specific target, but also  links to the developability in relation to the design of a desired drug delivery system.

Biopharmaceutical aspects are here defined as the interrelation of the drug/drug delivery system with biological matrices (e.g. blood, saliva, gastro-intestinal fluids, lung-lining fluids, mucus, epithelia, endothelia) and how this may influence delivery of the drug to exert the desired effect (e.g. effects on PK and PD).

Delivery of sufficient amounts of the active pharmaceutical ingredient (API) to therapeutic targets increasingly require the use of biopharmaceuticals (i.e. peptides, proteins, nucleic acids), but also small molecule drugs. Combination therapies and/or the application of functionalizing excipients and drug delivery systems.

The course will in a case-based manner focus on how to asses and in-depth evaluate drug delivery systems towards a translation from molecule to dosage form.

The course will be be class-room lectures (16x2 lectures; e.g. Tuesdays and Thursdays 8-10) supplemented with group work and presentations by the students.

Learning Outcome

At the end of the course, students are expected to be able to:

 

Knowledge

  • identify and explain biopharmaceutical aspects in drug research and development (i.e. be able to consider drugability and developability of drugs/drug delivery systems)
  • refere state-of-the-art methodologies for assessment of biopharmaceutical aspects in drug delivery

 

Skills

  • select and use relevant scientific information in relation to planning and executing the biopharmaceutical evaluation of a given drug/drug delivery system
  • plan, prepare and present (examples of) laboratory protocols 
  • evaluate experimental data and relate to findings 

1) selected text book material/chapters

2) scientific literature

3) experimental data and protocol examples

 

Lectures, supervised group work and student presentations (written/oral) with peer-reviewing
Oral
Continuous feedback during the course of the semester
Peer feedback (Students give each other feedback)
Credit
7,5 ECTS
Type of assessment
Continuous assessment
To obtain a course certificate the students should:
*Take part in group presentation of written and oral work.
*Take part in group preparation and presentation of a plan for detailed assessment of a selected drug and drug delivery system with special emphasis on the relevant biopharmaceurtical aspects.
*Participate in peer-review of the work of other groups
*Carry out protocols (s) of laboratory tests
*Participate satisfactorily throughout the course.
Evaluations are done by the course teachers (as "invited evaluation panel").
Aid
All aids allowed
Marking scale
passed/not passed
Censorship form
No external censorship
Criteria for exam assesment

To obtain a course certificate the students should be able to:

 

Knowledge

  • identify and explain biopharmaceutical aspects in drug research and development (i.e. be able to consider drugability and developability of drugs/drug delivery systems)
  • refere state-of-the-art methodologies for assessment of biopharmaceutical aspects in drug delivery

 

Skills

  • select and use relevant scientific information in relation to planning and executing the biopharmaceutical evaluation of a given drug/drug delivery system
  • plan, prepare and present (examples of) laboratory protocols 
  • evaluate experimental data and relate to findings 
  • outline and briefly explain relevant biopharmaceutical information required to evaluate a certain drug/drug delivery system
  • outline protocol(s) for how to test some of the above in the laboratory

 

 

  • Category
  • Hours
  • Preparation
  • 110
  • Lectures
  • 32
  • Class Instruction
  • 16
  • Colloquia
  • 16
  • Project work
  • 32
  • Total
  • 206