SBRI19015U Clinical Translational Medicine

On completion of the course, the participants should be able to:

Knowledge

• Relate how thorough characterization (molecular, immunological, imaging) of the individual patient or patient’s samples may be used for direct selection of patient treatment/care
• Explain how information from biological experiments (in vitro and animal models) can be used as a platform for designing investigations in patients
• Discuss how biological experiments may lead to drug development
• Describe how to bring a preclinical drug to phase 1, basic requirements
• Describe Phase 1 -> 3 trials
• Plan a translational study with material from a clinical trial
• Describe different studies, non-inferior vs. superiority studies

Skills

• Integrate knowledge obtained from all other courses into translational clinical research
• Critically evaluate preclinical data -  from a clinical point of view
• Generate novel ideas for clinical trials from preclinical observations
• Implement research results in clinical practice
• Solve unmet clinical needs/questions by designing the clinically relevant preclinical/ biological experiments

Competences

• Integrate  basic biology  into clinical knowledge
• Assess ethical considerations of how to implement new molecular tools and conduct studies with patients
• Understand the central aspects of clinical translational medicine and be able to discuss and communicate these to other scientists, clinicians, and the public