NBIK16001U  NMR Spectroscopy

Volume 2017/2018
Education

MSc Programme in Biochemistry
MSc Programme in Chemistry
MSc Programme in Nanoscience
MSc Programme in Physics

Content

The aim of the course is for the student to learn basic density operator theory applied to nuclear magnetic resonance (NMR) spectroscopic experiments. This theoretical foundation will be used to analyze how various 1D and multidimensional NMR experiments can be applied for molecular identification and in the study of molecular structure and dynamics. Topics covered will include nuclear spin, chemical shift, scalar and dipolar couplings, relaxation, multi-dimensional spectroscopy, solid-state NMR and the NMR spectrometer. The concepts will be demonstrated by spectra of biological molecules such as proteins, carbohydrates and complex mixtures of metabolites.

Learning Outcome

Having followed this course the student should have acquired the following:

Knowledge:

  • About the basic properties of nuclear spin and density operator theory
  • About chemical shift,
  • About multidimensional NMR spectroscopy
  • About basic solid-state NMR
  • About the components of an NMR spectrometer
  • About signal acquisition and processing


Skills:

  • Be able to process 1D and multidimensional experimental NMR data
  • Be able to analyze NMR spectra for assignment of chemical shifts
  • Be able to analyze the data from T1 and T2 relaxation experiments
  • Be able to calculate the effect of basic NMR pulse sequences
  • Be able to interpret basic NMR spectra in terms of molecular structure and dynamics
  • Be able to plan an NMR spectroscopic experiment


Competences:

After the course the student will have competences in critically evaluating and discussing NMR spectroscopic experiments and the results of these. The student will have competences in presenting and discussing NMR spectroscopy in a precise and comprehensive scientific language.

See Absalon.

This course will assume previous knowledge of very basic applied NMR spectroscopy corresponding to what is taught in organic chemistry.
Lectures, colloquia and lab excercises. NMR software.
Credit
7,5 ECTS
Type of assessment
Written examination, 4 hours under invigilation
---
Exam registration requirements

7 written assignments handed in during the course.

 

Aid
Without aids
Marking scale
7-point grading scale
Censorship form
No external censorship
Several internal examiners
Re-exam

As ordinary.

If less than 10 students are enrolled, the exam will be an oral examination in 25 minutes, with no preparation.

The 7 written assignments must be handed in and approved by the teacher no later than two weeks before the reexamination. 

Criteria for exam assesment

The grade 12 is given for an outstanding performance demonstrating complete fulfillment of the under "Learning outcome" described, with no or few minor weaknesses.

  • Category
  • Hours
  • Lectures
  • 14
  • Colloquia
  • 28
  • Laboratory
  • 4
  • Theory exercises
  • 14
  • Preparation
  • 142
  • Exam
  • 4
  • Total
  • 206