NBIA08004U Evolutionary Medicine

Volume 2019/2020
Education

MSc Programme in Biology
MSc Programme in Biochemistry
MSc Programme in Molecular Biomedicine

MSc Programme in Biology with a minor subject

Content

Basic concepts in Evolutionary Medicine: The history and variation of human genes and their global spatial patterns; medically relevant genomic variation of human populations; genetic variation for alcoholism and lactose intolerance; genetic conflicts in pregnancy and childhood; MHC variation and immunity, spontaneous abortions and mate choice; pathogen (social) evolution and biofilms; development and dissemination of bacterial resistance to antibiotics; virulence evolution in general and in response to vaccines; population structure and genomic variation in bacteria and viruses; emerging diseases; non-infectious and degenerative disease, including the evolution of aging; lifestyle, diet and disease; cancer as an evolutionary process.

Learning Outcome

To give students a thorough understanding of the issues in medical research and practice where evolutionary thought adds a demonstrably useful perspective. Students will gain a detailed perception of the ways in which natural selection, random events and history have shaped humans and their pathogens. The course will help students to integrate evolutionary and molecular approaches. Students completing the course will be able to:

  • explain important concepts and current hypotheses in evolutionary medicine
  • evaluate the impact of selection, drift and history on humans and pathogens
  • describe medically relevant genetic variation in humans and pathogens
  • explain the significance of reproductive conflicts between mother, father and child for medical issues in pregnancy
  • explain the evolution of antibiotic resistance and pathogen virulence
  • explain cancer and aging as evolutionary processes
  • independently retrieve and organize information from the scientific literature
  • present and discuss original scientific papers and reviews in evolutionary medicine.


Knowledge:

By completing the course the student will be able to understand and reflect on:

  • the history and variation of human genes and their global spatial patterns
  • medically relevant genomic variation of human populations
  • genetic variation for alcoholism and lactose intolerance
  • genetic conflicts in pregnancy and childhood
  • MHC variation and immunity, spontaneous abortions and mate choice
  • pathogen (social) evolution and biofilms
  • development and dissemination of bacterial resistance to antibiotics
  • virulence evolution in general and in response to vaccines
  • population structure and genomic variation in bacteria and viruses
  • emerging diseases; non-infectious and degenerative disease, including the evolution of aging
  • lifestyle, diet and disease; cancer as an evolutionary process.


Skills:

  • The course gives students a thorough understanding of the issues in medical research and practice where evolutionary thought adds a demonstrably useful perspective.
  • Students will gain a detailed perception of the ways in which natural selection, random events and history have shaped humans and their pathogens.
  • The course will help students to integrate evolutionary and molecular approaches.


Competences:

By completing the course the student can:

  • explain important concepts and current hypotheses in evolutionary medicine
  • evaluate the impact of selection, drift and history on humans and pathogens
  • describe medically relevant genetic variation in humans and pathogens
  • explain the significance of reproductive conflicts between mother, father and child for medical issues in pregnancy
  • explain the evolution of antibiotic resistance and pathogen virulence
  • explain cancer and aging as evolutionary processes
  • independently retrieve and organize information from the scientific literature
  • present and discuss original scientific papers and reviews in evolutionary medicine
  • present a coherent essay on a specific topic in this field of study

See Absalon.

Academic qualifications equivalent to a BSc degree is recommended.
About nine hours of lectures/​seminars/​student presentations per week for the first seven weeks. Students can either do an individual presentation of original research papers during these first seven weeks or participate in group work to present an overview of one of the five themes in the final symposium at the end of week 7. All students must hand in a 2-page essay on the topic of their oral presentation before the end of week 7 to take the oral exam.
  • Category
  • Hours
  • Colloquia
  • 27
  • Exam
  • 0,5
  • Lectures
  • 36
  • Preparation
  • 122,5
  • Project work
  • 20
  • Total
  • 206,0
Oral
Collective
Credit
7,5 ECTS
Type of assessment
Oral examination, 25 minutes
Individual oral examination with 30 minutes preparation. The first part of the exam is a discussion of a question handed out just before the oral exam. The second part consists of questions based on the material covered in the course compendium and lectures.
Exam registration requirements

To participate in the exam the students are obligated to attend 80% of the classes and hand in a 2-page essay.
 

Aid
Only certain aids allowed

Only course materials are allowed (textbook and Absalon posted material).
During the preparation, contact with the outside world via email, phone or any other web sources is not allowed.

Marking scale
7-point grading scale
Censorship form
No external censorship
Several internal examiners
Re-exam

The same as ordinary exam.

If the requirement of 80% attendance of the classes is not fulfilled, the student must submit one or more additional essay(s) in lieu of, and with content and length commensurate with, the missing attendance.
If the requirement of handing in a 2-page essay is not fulfilled, the requirement can be fulfilled before the reexam. The student must hand in the essay no later than three weeks before the reexam ends and the essay must be approved before the reexam.

Criteria for exam assesment

In order to obtain the grade 12 the student should convincingly and accurately demonstrate the knowledge, skills and competences described under Learning Outcome.