SLVKA0361U Pharmaceutical Analytical Chemistry
MSc in Pharmaceutical Sciences - compulsory for track 2 (Drug development)
MSc in Medicinal Chemistry - elective
Study groups and exercises constitute an integrated course package. The course provides a background for selecting and developing analytical methods and assessing the reliability of analytical data. A variety of analytical techniques are described with regard to their use in quantitative determination and identification. Teaching will focus on the design and use of apparatus as well as potential sources of error. There will also be focus on quality assurance and validation of analytical methods, including the significance of linearity, accuracy, precision, sensitivity, determination limits, blind values, selectivity and interference.
The students take turns giving presentations on the performed practical exercises and the finding of the exercises are discussed and related to the theory of the applied instrumentation. In the practical exercises, students work with fixed demonstrations of separation and detection methods. They simultaneously work on a project where they plan and try out a number of these techniques on a given drug. The analytical techniques are UV/VIS spectrophotometry, liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and atomic absorption spectrometry (AAS). The students carry out experiments in groups and submit a joint report. Reports are assessed by the teacher and discussed on return.
To enable students to develop and use analytical chemical
methods in connection with development of drug substances, as well
as identification and quality assessment of drugs and excipients.
At the end of the course, students should be able to:
Knowledge
explain the principles of the techniques, their areas of application and potential sources of error
understand the methodological terminology required for reading literature and writing reports
assess the reliability of analytical data
report experiments briefly, clearly and unambiguously.
Skills
- Perform quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied
- Perform validation of an analytical method
Competences
Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods
- D.C. Harris: Quantitative Chemical Analysis, 9th edition, W.H. Freeman and Company, New York, 2016.
- Compendium in Pharmaceutical Analytical Chemistry, latest edition, Department of Pharmacy, University of Copenhagen. Is available on the course home page via Absalon.
•Discussion classes: 8 two-hour sessions
- Category
- Hours
- Practical exercises
- 64
- Preparation
- 36
- Project work
- 106
- Total
- 206
Compulsory for track 2 (Drug Development) of the MSc programme in Pharmaceutical Sciences.
- Credit
- 7,5 ECTS
- Type of assessment
- Written examination, 2 hours under invigilationMultiple choice exam
- Aid
All written aids allowed
Refer to the IT exams homepage link where the standard programs and IT tools available for the students’ disposal during IT exams under The Faculty of Health and Medical Sciences are listed.
Use of books, notes, lecturs slides etc. is permitted, also if the materials are on digital form on a USB flash drive.
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Criteria for exam assesment
To achieve the grade 12 the student must be able to:
Knowledge
explain the principle of the techniques, their areas of application and potential sources of error
understand the methodological terminology required for reading literature and writing reports
assess the reliability of analytical data
report experiments briefly, clearly and unambiguously.
Skills
- Perform quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied
- describe the analytical methods applied in selected reports and demonstrate ability to perform quantitative determinations based on analytical data.
Competences
Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods
Course information
- Language
- English
- Course code
- SLVKA0361U
- Credit
- 7,5 ECTS
- Level
- Full Degree Master
- Duration
- 1 block
- Placement
- Block 3
- Schedule
- A
- Course capacity
- 30 students
- Study board
- Study Board of Pharmaceutical Sciences
Contracting department
- Department of Pharmacy
Course responsibles
- Christian Janfelt (17-6d727c737d7e736b7838746b78706f767e4a7d7f786e38757f386e75)