SFKKM9021U Advanced Synthetic Organic Chemistry
MSc in Pharmaceutical Sciences - elective
MSc in Medicinal Chemistry - elective
Cand.Scient.Pharm. - elective
Cand.Pharm. - elective
Bachelor in pharmacy - elective
Working in groups of two, students will be assigned 2-3 projects
of varying length and difficulty. Students will develop practical
skills by working with different synthetic organic transformations
relevant to all settings where synthetic organic chemistry is
implemented, especially the drug discovery process in the
pharmaceutical industry. The different projects will all be
directly linked to ongoing research projects at the Faculty of
Pharmaceutical Sciences, and the prepared compounds will be used by
researchers at the Faculty at the end of the course.Students will
get acquainted with complex reaction set-ups, i.e. working with
very reactive, moisture- and oxygen-sensitive substances and
reagents. Literature searches in on-line databases as
Reaxys® (formerly Beilstein
Crossfire), SciFinder Scholar, Science of
Synthesis and Pharmaceutical Substances will be
introduced generally and will also be an integrated part of the
report that is to be submitted at the end of the course. A thorough
search of possible alternatives to the methods used during the
course must be made and evaluated, which gives students the skills
to select between different procedures from a wide array of
possible reagents and conditions. In the evaluation of the reports,
emphasis will be put on whether the experimental work is described
in such detail and quality that it meets the standards required for
publication in international peer-reviewed chemistry journals. This
includes the characterisation and verification of the purity of the
material that has been synthesized. Using no other source of
information, it should be possible for other students on the course
to reproduce the experiments described in the report.
Furthermore, a literature survey should be described, including a
discussion of the different options. A comparison of the different
reagents and conditions used should form the basis for the
selection of alternate synthetic strategies other than the ones
implemented during the course.
Objective
To build the student’s knowledge of applied synthetic organic chemistry as well as to illustrate different methods, techniques and equipment. To teach participants to combine literature work and theoretical knowledge with laboratory work. Students will be trained in the use of handbooks, primary literature and on-line databases to enable them to address practical implementation when choosing between different synthetic routes.
At the end of the course, students are expected to be able to:
Knowledge
- Familiar with a wide selection of techniques and equipment routinely used in a modern synthetic organic chemistry laboratory.
Skills
- Able to perform/reproduce a synthetic procedure based on descriptions in the primary litterature - including selection of relevant equipment.
- Able to conduct a literature search on a synthetic sequence with the goal of identifying possible solutions.
- Able to conduct literature searches in relevant databases to find information about specific substances and reagents, incl. commercial availability and safety issues etc.
Competences
- Able to select between and execute different methods of isolating organic substances, including determination of the identity and purity of compounds.
- Able to evaluate and compare different synthesis procedures with regard to practical implementation. Factors such as cost, toxicity and problems with handling sensitive reagents and starting materials should all be considered.
- Able do communicate in writing and present their experimental work in such a way that they adhere to the standards used when publishing results in the primary litterature.
Primarily scientific papers from chemical literature, supplemented by Michael C. Pirrung’s: The Synthetic Organic Chemist's Companion, 1. Ed. 2007, Wiley.
•Literature searches: 4 hours
- Category
- Hours
- Colloquia
- 25
- Practical exercises
- 80
- Preparation
- 101
- Total
- 206
Open for Danish and international guest students. For application details look here: http://sund.ku.dk/uddannelse/andre-uddannelsestilbud/meritstuderende/.
- Credit
- 7,5 ECTS
- Type of assessment
- Course participationWritten assignmentcourse certificate
Examination type:
To achieve a course certificate the students must in groups prepare a report detailing one of the projects they have been working on, including a section with a literature search relevant to the project. Subsequently, the students must present all aspects of their project (approx. 15 min presentation) at the final seminar.
The report should be written as a original research paper using a predefinded template. The quality of the report in combination with the oral presentation will form the basis of the final evaluation. - Exam registration requirements
Active participation in the experimental laboratory work.
- Marking scale
- passed/not passed
- Censorship form
- No external censorship
Criteria for exam assesment
To pass the course the student must be able to:
Knowledge
- Familiar with a wide selection of techniques and equipment routinely used in a modern synthetic organic chemistry laboratory.
Skills
- Able to perform/reproduce a synthetic procedure based on descriptions in the primary litterature - including selection of relevant equipment.
- Able to conduct a literature search on a synthetic sequence with the goal of identifying possible solutions.
- Able to conduct literature searches in relevant databases to find information about specific substances and reagents, incl. commercial availability and safety issues etc.
Competences
- Able to select between and execute different methods of isolating organic substances, including determination of the identity and purity of compounds.
- Able to evaluate and compare different synthesis procedures with regard to practical implementation. Factors such as cost, toxicity and problems with handling sensitive reagents and starting materials should all be considered.
- Able do communicate in writing and present their experimental work in such a way that they adhere to the standards used when publishing results in the primary litterature.
Course information
- Language
- English
- Course code
- SFKKM9021U
- Credit
- 7,5 ECTS
- Level
- Full Degree MasterBachelor choice,Full Degree Master choice
- Duration
- 1 block
- Placement
- Block 3
- Schedule
- B
- Course capacity
- 48 students
Reserved students at the MSc programme in Pharmaceutical Sciences. - Study board
- Study Board of Pharmaceutical Sciences
Contracting department
- Department of Drug Design and Pharmacology
Course responsibles
- Jesper Langgaard Kristensen (17-6c6775726774306d746b757667707567704275777066306d7730666d)