SMIMB1041U Pharmacology
Please note this is course description is for the study year 2014/2015. For updated information on dates, prices etc. in other semesters please visit www.mind.ku.dk.
This course is a compulsory course at the Master's Programme
in Industrial Drug Development.
The course is intended for drug development professionals who need
knowledge about basic pharmacological concepts and other drug
developers and professionals who need a brush-up course on
pharmacology for continuing professional development (CPD).
Master’s level (second cycle higher education). Open for freelance
students who meet the admission criteria. Compulsory for MIND
students, elective for other part-time master's students.
(subject to study board approval).
The pharmacological concepts, methodologies and techniques are fundamental for modern drug development. As a discipline it does not fit in for one particular part of the drug development process. Instead it is applied at many occasions in the lifespan of a drug candidate. In this connection basic pharmacological knowledge is important for those who want to possess an integrated view on the effects and behaviour of the drug candidate from discovery to clinical development. The classical disciplines concerning pharmacodynamics and pharmacokinetics are addressed separately to be familiar with the theoretical background behind these disciplines. Pharmacology also bridges the preclinical phase with clinical trials and thus is central in the translation of animal data to the human situation.
The course will teach the basic concepts of general pharmacology. Emphasis is on pharmacokinetics with hands-on calculations. It runs over two days and is computer aided. There is focus on experimental in vitro and in vivo tools and on animal experimental models for various diseases including modern experimental techniques.
The course covers the following areas:
- General pharmacology (pharmacodynamics)
- Pharmacokinetics (basic concepts, extra vascular dosing using a one-compartment model, IV administration using 1- and 2 compartment models, elimination: metabolism and excretion, hands-on calculation in an Excel spreadsheet)
- Exploratory pharmacology (measurement of pharmacological effect, safety pharmacology)
- In vitropharmacology, concepts and methodology (ADME; biomarkers; metabolism; transporters)
- In vivo pharmacology, methodology (animal models for cardiovascular diseases, obesity, bone and joint diseases and pain; behavioural animal models.)
Upon completion of the course, participants are expected to be able to:
Knowledge
- pin-point the role of pharmacology in the drug development process
- demonstrate basic knowledge of pharmacology
- its basic concepts regarding PD and PK
- its in vitromodels
- its in vivomodels
- its experimental tools
- identify basic pharmacokinetic parameters
- identify safety pharmacology aspects
Skills
- interpret raw pharmacodynamic data sets
- calculate and interpret raw pharmacokinetic data sets
- rank compounds delivered from discovery for further handling in development
- conduct validation applied in in vitromethods
- conduct validation applied in in vivo methods
Competencies
- integrate a pharmacology perspective in the planning of the various stages of the drug development process
- handle translational aspects in a pharmacological perspective
- communicate professionally using pharmacology terminology
The syllabus comprises collections of review papers, textbook chapters, case stories and hand-outs from course presentations, in total approximately 250 pages.
• A relevant bachelor degree or equivalent
• A minimum of 2 years of relevant job experience
• Proficiency in English
- Category
- Hours
- Class Instruction
- 35
- Exam
- 2
- Exam Preparation
- 8
- Preparation
- 23,75
- Total
- 68,75
Application deadline: 1 March 2015. Closed for applications.
- Credit
- 2,5 ECTS
- Type of assessment
- Written examination, 2 under invigilationProblems based on a case description, supplemented with multiple choice and short essay questions.
- Aid
- Written aids allowed
Apart from the standard programs and IT tools listed under The Faculty of Health and Medical Sciences at http://pc-eksamen.ku.dk/pc_exam students will at this exam also have access to use a USB stick (for notes etc.)
Calculators are not allowed. - Marking scale
- 7-point grading scale
- Censorship form
- External censorship
- Exam period
Exam on the last day of the course 11 May 2015 at 2-4 pm
Criteria for exam assesment
The grade 12 is given when the examinee:
- demonstrates a well structured presentation with a clear outline providing exact and correct answers
- demonstrates aplomb comprehensive view
- combines convincingly the learned elements
- demonstrates with few unimportant deficits: aplomb mastering of relevant terms, principles and methods used in non-clinical pharmacological characterization in the development process of a new chemical entity
The grade 7 is given when the examinee:
- demonstrates a coherent presentation providing understandable unambiguous answers, the great majority of which should be correct
- documents a certain overview over the learned elements
- demonstrates with minor deficits a firm knowledge of relevant terms, principles and methods used in non-clinical pharmacological characterization in the development process of a new chemical entity
The grade 02 is given when the examinee:
- demonstrates a less structured presentation with less precise answers
- demonstrates a limited overview, and the ability to combine learned elements is limited
- demonstrates only a limited extent and with a number of deficits capability to handle relevant terms, principles and methods used in non-clinical pharmacological characterization in the development process of a new chemical entity
Course information
- Language
- English
- Course code
- SMIMB1041U
- Credit
- 2,5 ECTS
- Level
- Part Time Master
- Duration
- 5-8 May + 11 May 2015
- Placement
- Spring
- Schedule
- 5 days
- Course capacity
- 25 participants
- Continuing and further education
- Price
Part-time master’s students at School of Pharmaceutical Sciences DKK 9,240, freelance students DKK 10,700, freelance students from non-EU/EEA countries DKK 12,640. Fee includes course materials and meals. Prices may be subject to change.
- Study board
- Study Board for Part-time Master’s Programmes of Pharmaceutical Sciences
Contracting department
- Department of Drug Design and Pharmacology
Course responsibles
- Anne-Marie Heegaard (4-636f6a674275777066306d7730666d)
Anette Sams sams@epoqe.dk
Lecturers
List of lecturers may be subject to change.
Anne-Marie Heegaard, University of Copenhagen
Bente Steffansen, University of Copenhagen
Bjarke Ebert, H. Lundbeck
Darryl Pickering, University of Copenhagen
Frank Larsen, H. Lundbeck
Helle Waagepetersen, University of Copenhagen
Inge de Jong, H. Lundbeck
Jørgen Olsen, Novo Nordisk
Kim Kristensen, Novo Nordisk
Kim Sonne, LEO Pharma
Lasse Tengbjerg Hansen, Novo Nordisk
Majid Sheykhzade, University of Copenhagen
Mette Guldbrandt, Novo Nordisk
Ole J. Bjerrum, University of Copenhagen
Peter B. Johansen, Novo Nordisk
Uffe Kristiansen, University of Copenhagen